Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder/Experiment 1
From BugSigDB
Needs review
Subjects
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Intestine Bowel,Intestinal tract,Intestine,intestine
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Parkinson's disease IDIOPATHIC PARKINSON DIS,Idiopathic Parkinson Disease,Idiopathic Parkinson's Disease,IDIOPATHIC PARKINSONS DIS,Idiopathic PD,LEWY BODY PARKINSON DIS,Lewy Body Parkinson Disease,Lewy Body Parkinson's Disease,Paralysis agitans,paralysis agitans,PARKINSON DIS,PARKINSON DIS IDIOPATHIC,Parkinson disease,Parkinson Disease, Idiopathic,Parkinson syndrome,Parkinson's,Parkinson's disease,Parkinson's disease (disorder),Parkinson's disease NOS,Parkinson's disease NOS (disorder),Parkinson's Disease, Idiopathic,Parkinson's Disease, Lewy Body,Parkinson's syndrome,Parkinsonian disorder,Parkinsonism, Primary,Parkinsons,PARKINSONS DIS,PARKINSONS DIS IDIOPATHIC,PARKINSONS DIS LEWY BODY,Parkinsons disease,Primary Parkinsonism,parkinson's disease
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Rapid-eye-movement sleep behavior disorder (iRBD) patients
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients with idiopathic rapid-eye-movement sleep behavior disorder (iRBD) diagnosed according to the International Classification of Sleep Disorders Criteria-Third Edition
- Group 0 sample size Number of subjects in the control (unexposed) group
- 137
- Group 1 sample size Number of subjects in the case (exposed) group
- 26
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 1 month
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, sex, constipation, proton-pump inhibitor
Signature 1
Source: Figure 4
Description: Read counts of genera Akkermansia, Faecalibacterium, Roseburia, and Lachnospiraceae ND3007 group normalized for 1 × 104 reads in controls, iRBD, and Hoehn and Yahr scales 1 to 5.
Abundance in Group 1: increased abundance in Rapid-eye-movement sleep behavior disorder (iRBD) patients
| NCBI | Quality Control | Links |
|---|---|---|
Revision editor(s): Aishat
Signature 2
Source: Figure 4
Description: Read counts of genera Akkermansia, Faecalibacterium, Roseburia, and Lachnospiraceae ND3007 group normalized for 1 × 104 reads in controls, iRBD, and Hoehn and Yahr scales 1 to 5.
Abundance in Group 1: decreased abundance in Rapid-eye-movement sleep behavior disorder (iRBD) patients
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia | ||
| Faecalibacterium | ||
| Roseburia |
Revision editor(s): Aishat
