Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease

From BugSigDB
Needs review
Citation
PMID PubMed identifier for scientific articles.
DOI Digital object identifier for electronic documents.
URI
Authors
Zhou X, Shen X, Johnson JS, Spakowicz DJ, Agnello M, Zhou W, Avina M, Honkala A, Chleilat F, Chen SJ, Cha K, Leopold S, Zhu C, Chen L, Lyu L, Hornburg D, Wu S, Zhang X, Jiang C, Jiang L, Jiang L, Jian R, Brooks AW, Wang M, Contrepois K, Gao P, Rose SMS, Tran TDB, Nguyen H, Celli A, Hong BY, Bautista EJ, Dorsett Y, Kavathas PB, Zhou Y, Sodergren E, Weinstock GM, Snyder MP
Journal
Cell host & microbe
Year
2024
Keywords:
insulin resistance, longitudinal profiling, microbiome host interaction, microbiome stability, nasal microbiome, oral microbiome, precision medicine, prediabetes, skin microbiome, stool microbiome
To understand the dynamic interplay between the human microbiome and host during health and disease, we analyzed the microbial composition, temporal dynamics, and associations with host multi-omics, immune, and clinical markers of microbiomes from four body sites in 86 participants over 6 years. We found that microbiome stability and individuality are body-site specific and heavily influenced by the host. The stool and oral microbiome are more stable than the skin and nasal microbiomes, possibly due to their interaction with the host and environment. We identify individual-specific and commonly shared bacterial taxa, with individualized taxa showing greater stability. Interestingly, microbiome dynamics correlate across body sites, suggesting systemic dynamics influenced by host-microbial-environment interactions. Notably, insulin-resistant individuals show altered microbial stability and associations among microbiome, molecular markers, and clinical features, suggesting their disrupted interaction in metabolic disease. Our study offers comprehensive views of multi-site microbial dynamics and their relationship with host health and disease.

Experiment 1


Needs review

Curated date: 2024/04/07

Curator: Joan Chuks

Revision editor(s): Joan Chuks, Adeitan

Subjects

Location of subjects
United States of America
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Insulin sensitivity measurement insulin sensitivity test,Insulin sensitivity measurement,insulin sensitivity measurement
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Insulin Sensitive (IS) Individuals
Group 1 name Corresponds to the case (exposed) group for case-control studies
Insulin Resistant (IR) Individuals
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Individuals who are at risk for type 2 diabetes or voluntarily interested in diabetes-related research, whose steady-state plasma glucose (SSPG) was greater than or equal to 150 mg/dl after undergoing Glucose control assessments, comprising an annual oral glucose tolerance test and a gold-standard steady-state plasma glucose (SSPG) measurement.
Group 0 sample size Number of subjects in the control (unexposed) group
28
Group 1 sample size Number of subjects in the case (exposed) group
30
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
No

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V1-V3
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
2
Matched on Factors on which subjects have been matched on in a case-control study
date

Alpha Diversity

Pielou Quantifies how equal the community is numerically
unchanged
Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Richness Number of species
decreased

Signature 1

Needs review

Curated date: 2024/04/08

Curator: Joan Chuks

Revision editor(s): Joan Chuks, Adeitan

Source: Table S1D + Figure S1M

Description: Taxa Differing in Abundance Between Insulin Sensitive and Insulin Resistant Individuals as determined by Linear discriminant analysis Effect Size (LEFSe)

Abundance in Group 1: increased abundance in Insulin Resistant (IR) Individuals

NCBI Quality ControlLinks
Agathobacter
Anaerotignum
Bacteroidaceae
Bacteroidales
Bacteroides thetaiotaomicron
Bacteroidia
Bacteroidota
Blautia
Enterococcaceae
Enterococcus
Lachnospiraceae
Phocaeicola
s__Unclassified_Phocaeicolas__Unclassified_Phocaeicola
s__Unclassified_Agathobacters__Unclassified_Agathobacter
s__unclassified Blautias__unclassified Blautia
s__unclassified Bacteroidaceaes__unclassified Bacteroidaceae
s__Unclassified_Enteroclosters__Unclassified_Enterocloster
s__Unclassified_Anaerotignums__Unclassified_Anaerotignum
Enterocloster
g__Unclassified_Bacteroidaceaeg__Unclassified_Bacteroidaceae

Revision editor(s): Joan Chuks, Adeitan

Signature 2

Needs review

Curated date: 2024/04/08

Curator: Joan Chuks

Revision editor(s): Joan Chuks

Source: Table S1D + Figure S1M

Description: Taxa Differing in Abundance Between Insulin Sensitive and Insulin Resistant Individuals as determined by Linear discriminant analysis Effect Size (LEFSe)

Abundance in Group 1: decreased abundance in Insulin Resistant (IR) Individuals

NCBI Quality ControlLinks
Actinomycetes
Acutalibacter
Barnesiellaceae
Beduinibacterium
Bifidobacteriaceae
Bifidobacteriales
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium longum
Butyricicoccus
Christensenella
Colidextribacter
Coprobacillus
Coprococcus
Corynebacteriaceae
Corynebacterium
Desulfovibrio
Desulfovibrio desulfuricans
Eubacteriales Family XIII. Incertae Sedis
Faecalicatena
Haemophilus
Ihubacter
Kiloniellaceae
Kineothrix
Lachnotalea
Mailhella
Mogibacterium
Monoglobus
Mycobacteriales
Odoribacter
Odoribacteraceae
Oscillibacter
Oscillospiraceae
Oxalobacter
Oxalobacteraceae
Pasteurellaceae
Pasteurellales
Porphyromonas
Porphyromonas gingivalis
Rhodospirillales
Synergistaceae
Synergistales
Synergistia
Synergistota
Turicibacter
Turicibacter sanguinis
g__Unclassified_Ruminococcaceaeg__Unclassified_Ruminococcaceae
s__Unclassified_Ruminococcaceaes__Unclassified_Ruminococcaceae
f__Unclassified_Clostridialesf__Unclassified_Clostridiales
g__Unclassified_Clostridialesg__Unclassified_Clostridiales
s__Unclassified_Clostridialess__Unclassified_Clostridiales
s__Unclassified_Oscillibacters__Unclassified_Oscillibacter
g__Unclassified_Bacteroidalesg__Unclassified_Bacteroidales
f__Unclassified_Bacteroidalesf__Unclassified_Bacteroidales
s__Unclassified_Bacteroidaless__Unclassified_Bacteroidales
s__Unclassified_Colidextribacters__Unclassified_Colidextribacter
s__Unclassified_Oxalobacters__Unclassified_Oxalobacter
s__Unclassified_Haemophiluss__Unclassified_Haemophilus
s__Unclassified_Mailhellas__Unclassified_Mailhella
s__Unclassified_Erysipelotrichaceaes__Unclassified_Erysipelotrichaceae
g__Unclassified_Erysipelotrichaceaeg__Unclassified_Erysipelotrichaceae
g__Unclassified_Firmicutesg__Unclassified_Firmicutes
c__Unclassified_Firmicutesc__Unclassified_Firmicutes
o__Unclassified_Firmicuteso__Unclassified_Firmicutes
s__Unclassified_Firmicutess__Unclassified_Firmicutes
f__Unclassified_Firmicutesf__Unclassified_Firmicutes
s__Unclassified_Coprococcuss__Unclassified_Coprococcus
s__Unclassified_Kineothrixs__Unclassified_Kineothrix
g__Unclassified_Clostridiaceae_1g__Unclassified_Clostridiaceae_1
s__Unclassified_Clostridiaceae_1s__Unclassified_Clostridiaceae_1
s__Unclassified_Desulfovibrios__Unclassified_Desulfovibrio
s__Unclassified_Odoribacters__Unclassified_Odoribacter
s__Unclassified_Coprobacilluss__Unclassified_Coprobacillus
s__Unclassified_Beduinibacteriums__Unclassified_Beduinibacterium
s__Unclassified_Ihubacters__Unclassified_Ihubacter
s__Unclassified_Turicibacters__Unclassified_Turicibacter
s__Unclassified_Butyricicoccuss__Unclassified_Butyricicoccus
s__Unclassified_Monoglobuss__Unclassified_Monoglobus
s__Unclassified_Lachnotaleas__Unclassified_Lachnotalea
g__Unclassified_Eggerthellaceaeg__Unclassified_Eggerthellaceae
s__Unclassified_Eggerthellaceaes__Unclassified_Eggerthellaceae
s__Unclassified_Faecalicatenas__Unclassified_Faecalicatena
s__Unclassified_Catabacters__Unclassified_Catabacter
s__Unclassified_Acutalibacters__Unclassified_Acutalibacter

Revision editor(s): Joan Chuks

Experiment 2


Needs review

Curated date: 2024/04/08

Curator: Joan Chuks

Revision editor(s): Joan Chuks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Skin of body Entire integument,Entire skin,Integument,Integumental organ,Pelt,Skin,Skin organ,Skin of body,skin of body


Lab analysis

16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4

Statistical Analysis

Alpha Diversity

Pielou Quantifies how equal the community is numerically
increased
Shannon Estimator of species richness and species evenness: more weight on species richness
increased
Richness Number of species
increased

Signature 1

Needs review

Curated date: 2024/04/12

Curator: Joan Chuks

Revision editor(s): Joan Chuks

Source: Table S1D + Figure S1M

Description: Taxa Differing in Abundance Between Insulin Sensitive and Insulin Resistant Individuals as determined by Linear discriminant analysis Effect Size (LEFSe)

Abundance in Group 1: increased abundance in Insulin Resistant (IR) Individuals

NCBI Quality ControlLinks
Aggregatibacter segnis
Alishewanella
Alloprevotella
Alloprevotella tannerae
Anaerococcus octavius
Anaerococcus provencensis
Anaerococcus vaginalis
Aquihabitans daechungensis
Atopobium
Bacteroidales
Bacteroidia
Bacteroidota
Campylobacter
Campylobacter showae
Campylobacter ureolyticus
Campylobacteraceae
Campylobacterales
Campylobacterota
Candidatus Saccharibacteria
Capnocytophaga sputigena
Clostridia
Coriobacteriia
Desulfovibrionaceae
Dialister micraerophilus
Dietzia
Dietziaceae
Empedobacter
Epsilonproteobacteria
Ethanoligenens
Eubacteriaceae
Eubacteriales
Eubacteriales Family XIII. Incertae Sedis
Eubacterium
Facklamia languida
Flavobacteriales
Flavobacteriia
Flavobacterium lindanitolerans
Fulvivirgaceae
Gardnerella
Gemmataceae
Intrasporangiaceae
Intrasporangium
Kingella
Kingella oralis
Lawsonella
Lawsonellaceae
Lysobacter
Megasphaera
Methylophilus
Micropruina
Mogibacterium
Negativicoccus
Negativicutes
Ohtaekwangia
Paracoccus siganidrum
Peptoniphilaceae
Peptoniphilus
Porphyromonas bennonis
Prevotella
Prevotella bivia
Prevotella histicola
Prevotella melaninogenica
Prevotella nigrescens
Prevotellaceae
Rickettsiella
Rothia koreensis
Segatella salivae
Tepidimonas
Thermoactinomycetaceae
Veillonellaceae
Veillonellales
Weeksellaceae
c__Armatimonadetes_gp5c__Armatimonadetes_gp5
s__Unclassified_Peptoniphiluss__Unclassified_Peptoniphilus
s__Unclassified_Oribacteriums__Unclassified_Oribacterium
s__Unclassified_Rhodospirillaless__Unclassified_Rhodospirillales
s__Unclassified_Armatimonadetes_gp5s__Unclassified_Armatimonadetes_gp5
o__Unclassified_Armatimonadetes_gp5o__Unclassified_Armatimonadetes_gp5
g__Unclassified_Rhodospirillalesg__Unclassified_Rhodospirillales
s__Unclassified_Eubacteriums__Unclassified_Eubacterium
g__Unclassified_Armatimonadetes_gp5g__Unclassified_Armatimonadetes_gp5
s__Unclassified_Empedobacters__Unclassified_Empedobacter
s__Unclassified_Tepidimonass__Unclassified_Tepidimonas
s__Unclassified_Aggregatibacters__Unclassified_Aggregatibacter
s__Unclassified_Ethanoligenenss__Unclassified_Ethanoligenens
s__Unclassified_Intrasporangiums__Unclassified_Intrasporangium
s__Unclassified_Methylophiluss__Unclassified_Methylophilus
s__Unclassified_Lawsonellas__Unclassified_Lawsonella
s__Unclassified_Negativicoccuss__Unclassified_Negativicoccus
s__Unclassified_Ohtaekwangias__Unclassified_Ohtaekwangia
s__Unclassified_Lysobacters__Unclassified_Lysobacter
s__Unclassified_Diplorickettsias__Unclassified_Diplorickettsia
f__Unclassified_Rhodospirillalesf__Unclassified_Rhodospirillales
s__Unclassified_Alishewanellas__Unclassified_Alishewanella
s__Unclassified_Blastocatellaceaes__Unclassified_Blastocatellaceae
g__Unclassified_Blastocatellaceaeg__Unclassified_Blastocatellaceae
f__Unclassified_Armatimonadetes_gp5f__Unclassified_Armatimonadetes_gp5
c__Unclassified_Candidatus_Saccharibacteriac__Unclassified_Candidatus_Saccharibacteria
o__Unclassified_Candidatus_Saccharibacteriao__Unclassified_Candidatus_Saccharibacteria
f__Unclassified_Candidatus_Saccharibacteriaf__Unclassified_Candidatus_Saccharibacteria
g__Unclassified_Candidatus_Saccharibacteriag__Unclassified_Candidatus_Saccharibacteria
s__Unclassified_Candidatus_Saccharibacterias__Unclassified_Candidatus_Saccharibacteria
s__Unclassified_Prevotellas__Unclassified_Prevotella
s__Unclassified_Lachnoanaerobaculums__Unclassified_Lachnoanaerobaculum
s__Unclassified_Mogibacteriums__Unclassified_Mogibacterium

Revision editor(s): Joan Chuks

Signature 2

Needs review

Curated date: 2024/04/12

Curator: Joan Chuks

Revision editor(s): Joan Chuks, Adeitan

Source: Table S1D + Figure S1M

Description: Taxa Differing in Abundance Between Insulin Sensitive and Insulin Resistant Individuals as determined by Linear discriminant analysis Effect Size (LEFSe)

Abundance in Group 1: decreased abundance in Insulin Resistant (IR) Individuals

NCBI Quality ControlLinks
Actinomycetota
Actinotignum
Barnesiella
Barnesiellaceae
Beijerinckiaceae
Cutibacterium
Dialister
Flavisolibacter
Lachnobacterium
Micrococcales
Paracoccaceae
Paracoccus
Propionibacteriales
Ralstonia
Roseburia
Sphingomonadaceae
Sphingomonadales
Sphingomonas
Staphylococcus haemolyticus
Xanthomonas
Aurantimonadaceae
Paracoccus yeei
'Sphingomonas ginsengisoli' Hoang et al. 2012
s__Unclassified_Actinotignums__Unclassified_Actinotignum
s__Unclassified_Barnesiellas__Unclassified_Barnesiella
s__Unclassified_Roseisolibacters__Unclassified_Roseisolibacter
g__Unclassified_Beijerinckiaceaeg__Unclassified_Beijerinckiaceae
s__Unclassified_Lachnobacteriums__Unclassified_Lachnobacterium
s__Unclassified_Beijerinckiaceaes__Unclassified_Beijerinckiaceae
s__Unclassified_Flavisolibacters__Unclassified_Flavisolibacter
s__Unclassified_Dialisters__Unclassified_Dialister
s__Unclassified_Roseburias__Unclassified_Roseburia
Patulibacter minatonensis
Roseisolibacter
Rhodobacterales
s__Unclassified_Ralstonias__Unclassified_Ralstonia
s__Unclassified_Sphingomonass__Unclassified_Sphingomonas
s__Unclassified_Xanthomonass__Unclassified_Xanthomonas

Revision editor(s): Joan Chuks, Adeitan

Experiment 3


Needs review

Curated date: 2024/04/12

Curator: Joan Chuks

Revision editor(s): Joan Chuks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Anterior naris Anterior nostril,Anterior naris,anterior naris


Lab analysis

16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V1-V3

Statistical Analysis

Alpha Diversity

Pielou Quantifies how equal the community is numerically
unchanged
Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Richness Number of species
unchanged

Signature 1

Needs review

Curated date: 2024/04/12

Curator: Joan Chuks

Revision editor(s): Joan Chuks, Adeitan

Source: Table S1D

Description: Taxa Differing in Abundance Between Insulin Sensitive and Insulin Resistant Individuals as determined by Linear discriminant analysis Effect Size (LEFSe)

Abundance in Group 1: increased abundance in Insulin Resistant (IR) Individuals

NCBI Quality ControlLinks
Brevibacterium
Caulobacteraceae
Cytophagaceae
Micrococcus luteus
s__Unclassified_Caulobacteraceaes__Unclassified_Caulobacteraceae
g__Unclassified_Caulobacteraceaeg__Unclassified_Caulobacteraceae
Staphylococcus capitis
s__Unclassified_Brevibacteriums__Unclassified_Brevibacterium
s__Unclassified_Salinimicrobiums__Unclassified_Salinimicrobium
Salinimicrobium
Porphyromonas endodontalis
Anaerococcus senegalensis
s__Unclassified_Mycobacteriums__Unclassified_Mycobacterium

Revision editor(s): Joan Chuks, Adeitan

Signature 2

Needs review

Curated date: 2024/04/12

Curator: Joan Chuks

Revision editor(s): Joan Chuks

Source: Table S1D

Description: Taxa Differing in Abundance Between Insulin Sensitive and Insulin Resistant Individuals as determined by Linear discriminant analysis Effect Size (LEFSe)

Abundance in Group 1: decreased abundance in Insulin Resistant (IR) Individuals

NCBI Quality ControlLinks
Aerococcus
Anaerobutyricum
Anaerostipes
Bacteroides fragilis
Bacteroides thetaiotaomicron
Bacteroides xylanisolvens
Blastococcus
Butyricimonas
Capnocytophaga canimorsus
Chloroflexia
Coprococcus
Dorea longicatena
Enterocloster
Gammaproteobacteria
Geodermatophilaceae
Halomonadaceae
Halomonas
Helicobacteraceae
Ihubacter
Mollicutes
Monoglobus
Moraxella
Moraxellaceae
Neisseria flavescens
Nitriliruptoria
Oceanospirillales
Odoribacteraceae
Paludibacter
Rhodocyclales
Rhodospirillaceae
Sanguibacter
Segatella salivae
Subdoligranulum
Xanthomonas
s__Unclassified_Blastococcuss__Unclassified_Blastococcus
s__Unclassified_Subdoligranulums__Unclassified_Subdoligranulum
s__Unclassified_Moraxellas__Unclassified_Moraxella
s__Unclassified_Anaerobutyricums__Unclassified_Anaerobutyricum
s__Unclassified_Micrococcaless__Unclassified_Micrococcales
s__Unclassified_Paludibacters__Unclassified_Paludibacter
s__Unclassified_Monoglobuss__Unclassified_Monoglobus
s__Unclassified_Anaerobacters__Unclassified_Anaerobacter
s__Unclassified_Halomonass__Unclassified_Halomonas
s__Unclassified_Leuconostocs__Unclassified_Leuconostoc
s__Unclassified_Aerococcuss__Unclassified_Aerococcus
g__Unclassified_Micrococcalesg__Unclassified_Micrococcales
f__Unclassified_Micrococcalesf__Unclassified_Micrococcales
c__Armatimonadetes_gp5c__Armatimonadetes_gp5
o__Unclassified_Armatimonadetes_gp5o__Unclassified_Armatimonadetes_gp5
s__Unclassified_Butyricimonass__Unclassified_Butyricimonas
s__Unclassified_Clostridium_XlVas__Unclassified_Clostridium_XlVa
s__Unclassified_Coprococcuss__Unclassified_Coprococcus
s__Unclassified_Armatimonadetes_gp5s__Unclassified_Armatimonadetes_gp5
s__Unclassified_Clostridium_sensu_strictos__Unclassified_Clostridium_sensu_stricto
s__Unclassified_Microvirgas__Unclassified_Microvirga
s__Unclassified_Enteroclosters__Unclassified_Enterocloster
f__Unclassified_Armatimonadetes_gp5f__Unclassified_Armatimonadetes_gp5
s__Unclassified_Allorhizobiums__Unclassified_Allorhizobium
s__Unclassified_Odoribacters__Unclassified_Odoribacter
s__Unclassified_Ihubacters__Unclassified_Ihubacter
s__Unclassified_Anaerostipess__Unclassified_Anaerostipes
g__Unclassified_Armatimonadetes_gp5g__Unclassified_Armatimonadetes_gp5
Geodermatophilales
Clostridium
Azonexaceae
Gemella palaticanis
Allorhizobium
Sphingosinicellaceae
Microbacterium oleivorans
Methylobacillus
Microbacterium testaceum
Paludibacteraceae
Mycoplasmatota
g__Clostridium_XlVag__Clostridium_XlVa

Revision editor(s): Joan Chuks

Experiment 4


Needs review

Curated date: 2024/04/12

Curator: Joan Chuks

Revision editor(s): Joan Chuks

Differences from previous experiment shown

Subjects

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Posterior wall of oropharynx Posterior wall of oropharynx,posterior wall of oropharynx


Lab analysis

16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4

Statistical Analysis

Alpha Diversity

Pielou Quantifies how equal the community is numerically
unchanged
Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Richness Number of species
unchanged

Signature 1

Needs review

Curated date: 2024/04/12

Curator: Joan Chuks

Revision editor(s): Joan Chuks

Source: Table S1D

Description: Taxa Differing in Abundance Between Insulin Sensitive and Insulin Resistant Individuals as determined by Linear discriminant analysis Effect Size (LEFSe)

Abundance in Group 1: increased abundance in Insulin Resistant (IR) Individuals

NCBI Quality ControlLinks
Abiotrophia
Abiotrophia defectiva
Aerococcaceae
Erythrobacteraceae
Lachnoanaerobaculum umeaense
Olsenella
Prevotella micans
Staphylococcaceae
Staphylococcus
s__Unclassified_Aggregatibacters__Unclassified_Aggregatibacter
s__Unclassified_Staphylococcuss__Unclassified_Staphylococcus
s__Unclassified_Olsenellas__Unclassified_Olsenella
Cytophagales
Cytophagia

Revision editor(s): Joan Chuks

Signature 2

Needs review

Curated date: 2024/04/12

Curator: Joan Chuks

Revision editor(s): Joan Chuks, Adeitan

Source: Table S1D

Description: Taxa Differing in Abundance Between Insulin Sensitive and Insulin Resistant Individuals as determined by Linear discriminant analysis Effect Size (LEFSe)

Abundance in Group 1: decreased abundance in Insulin Resistant (IR) Individuals

NCBI Quality ControlLinks
Catonella
Clostridia
Cyanobacteriota
Filifactor
Lachnospiraceae
Oribacterium
Filifactor alocis
Eubacteriales
Oribacterium sinus
Pseudoleptotrichia goodfellowii
s__Unclassified_Centipedas__Unclassified_Centipeda
s__Unclassified_Catonellas__Unclassified_Catonella

Revision editor(s): Joan Chuks, Adeitan