Tumor microbiome diversity influences papillary thyroid cancer invasion/Experiment 14
From BugSigDB
Needs review
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Thyroid gland Glandula thyroidea,Thyroid,Thyroid gland,thyroid gland
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Antibody antibodies,Antibody,antibody
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Anti-thyroid-stimulating receptors (Anti-TSHR)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- The association between Anti-thyroid-stimulating receptors (Anti-TSHR) and microbial abundance in Papillary Thyroid Cancer (PTC) patients.
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- arcsine square-root
- Statistical test
- Spearman Correlation
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Needs review
Source: Figure 3b
Description: Heatmap of Spearman’s correlation analysis between the specific bacterial and thyroid diseases (AITD)-related antibodies.
Abundance in Group 1: decreased abundance in Anti-thyroid-stimulating receptors (Anti-TSHR)
| NCBI | Quality Control | Links |
|---|---|---|
| Klebsiella | ||
| Burkholderia | ||
| Caballeronia | ||
| Paraburkholderia |
Revision editor(s): Aleru Divine
