Tumor microbiome diversity influences papillary thyroid cancer invasion/Experiment 15

Needs review

Curated date: 2024/04/25

Curator: Aleru Divine

Revision editor(s): Aleru Divine

Host species Species from which microbiome was sampled. Contact us to have more species added.: Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology: Thyroid gland Glandula thyroidea,Thyroid,Thyroid gland,thyroid gland

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology: Antibody antibodies,Antibody,antibody

Group 1 name Corresponds to the case (exposed) group for case-control studies: Anti-thyroid peroxidase (Anti-TPO)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group: The association between Anti-thyroid peroxidase (Anti-TPO) and microbial abundance in Papillary Thyroid Cancer (PTC) patients.

16S variable region One or more hypervariable region(s) of the bacterial 16S gene: V3-V4

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance: Illumina

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).: arcsine square-root

Significance threshold p-value or FDR threshold used for differential abundance testing (if any): 0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?: Yes

Needs review

Curated date: 2024/04/25

Curator: Aleru Divine

Revision editor(s): Aleru Divine

Source: Figure 3b

Description: Heatmap of Spearman’s correlation analysis between the specific bacterial and thyroid diseases (AITD)-related antibodies.

Abundance in Group 1: decreased abundance in Anti-thyroid peroxidase (Anti-TPO)

Revision editor(s): Aleru Divine