Tumor microbiome diversity influences papillary thyroid cancer invasion/Experiment 9

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Curated date: 2024/04/25

Curator: Aleru Divine

Revision editor(s): Aleru Divine

Subjects

Location of subjects

China

Host species Species from which microbiome was sampled. Contact us to have more species added.

Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology

Thyroid gland Glandula thyroidea,Thyroid,Thyroid gland,thyroid gland

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Hormone endocrine,hormones,Hormone,hormone

Group 1 name Corresponds to the case (exposed) group for case-control studies

Thyroid-Stimulating Hormone (TSH)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

The association between Thyroid-Stimulating Hormone (TSH) and different microbial genera in Papillary Thyroid Cancer (PTC) patients.

Lab analysis

Sequencing type

16S

16S variable region One or more hypervariable region(s) of the bacterial 16S gene

V3-V4

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance

Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).

arcsine square-root

Statistical test

Spearman Correlation

Significance threshold p-value or FDR threshold used for differential abundance testing (if any)

0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?

Yes

Signature 1

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Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/04/25

Curator: Aleru Divine

Revision editor(s): Aleru Divine

Source: Figure 3a

Description: Heatmap of Spearman’s correlation analysis showing the relationship between the specific bacterial and thyroid-related hormones.

Abundance in Group 1: decreased abundance in Thyroid-Stimulating Hormone (TSH)

NCBI	Quality Control	Links
Carnobacterium
Prevotella
clostridia UCG-014clostridia UCG-014

Revision editor(s): Aleru Divine