A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs/Experiment 27
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-1-23
Curated date: 2024/04/02
Curator: Barrakat
Revision editor(s): Deacme, Victoria, Barrakat, KateRasheed
Subjects
- Location of subjects
- Japan
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Canis lupus familiaris
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Forelimb skin Anteriormost limb skin,Fore limb skin,Skin of fore limb,Skin of forelimb,Skin of upper limb,Upper limb skin,Wing skin,Forelimb skin,forelimb skin
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Atopic eczema allergic,allergic dermatitis,allergic form of dermatitis,Atopic Dermatitides,Atopic Dermatitis,Atopic dermatitis,atopic dermatitis and related conditions,Atopic dermatitis and related conditions (disorder),atopic eczema,Atopic Neurodermatitides,Atopic Neurodermatitis,Atopic neurodermatitis,Besnier's prurigo,Dermatitides, Atopic,Dermatitis, Atopic,Disseminated Neurodermatitides,Disseminated Neurodermatitis,eczema,Eczema, Atopic,Eczema, Infantile,eczematous dermatitis,Infantile Eczema,Neurodermatitides, Atopic,Neurodermatitides, Disseminated,Neurodermatitis, Atopic,Neurodermatitis, Disseminated,OTHER ATOPIC DERMATITIS,Other atopic dermatitis and related conditions,Atopic eczema
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- cAD Treat
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Dogs that were already diagnosed with cAD (canine atopic dermatitis) before the study cohort recruitment and had been on oclacitinib treatment
- Group 0 sample size Number of subjects in the control (unexposed) group
- 20
- Group 1 sample size Number of subjects in the case (exposed) group
- 10
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V1-V2
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Statistical test
- ANCOM
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.1
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-1-23
Source: Supplementary Table S7, Supplementary Table S4 and Figure 3
Description: Statistical summary of differentially abundant taxa between dog groups.
Abundance in Group 1: decreased abundance in cAD Treat
| NCBI | Quality Control | Links |
|---|---|---|
| Staphylococcus equorum | ||
| Curvibacter |
Revision editor(s): Barrakat, Deacme, KateRasheed
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-1-23
Source: Supplementary Table S3
Description: Statistical summary of differentially abundant taxa between dog groups.
Abundance in Group 1: increased abundance in cAD Treat
| NCBI | Quality Control | Links |
|---|---|---|
| Acidobacteriota |
Revision editor(s): KateRasheed
