Gut microbiota composition in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives

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DOI Digital object identifier for electronic documents.
Coello K, Hansen TH, Sørensen N, Munkholm K, Kessing LV, Pedersen O, Vinberg M
Brain, behavior, and immunity
Bipolar disorder, Gut microbiota, Microbiota, Newly diagnosed, Unaffected relatives
OBJECTIVE: An aberrant gut microbiota may be associated with a broad spectrum of diseases including mental illness. The gut microbiota is scarcely studied in bipolar disorder (BD). We examined the gut microbiota composition in patients with newly diagnosed BD, their unaffected first-degree relatives and healthy individuals. METHODS: Stool samples were collected from 113 patients with BD, 39 unaffected first-degree relatives and 77 healthy individuals and the microbiota was profiled using 16S rRNA gene amplicon sequencing. RESULTS: The gut microbiota community membership of patients with BD differed from that of healthy individuals (R2 = 1.0%, P = 0.008), whereas the community membership of unaffected first-degree relatives did not. Flavonifractor was present in 61% of patients with BD, 42% of their unaffected relatives and 39% of healthy individuals. Presence of Flavonifractor was associated with an odds ratio of 2.9 (95%CI: 1.6-5.2, P = 5.8 × 10-4, Q = 0.036) for having BD. When excluding smokers, presence of Flavonifractor was associated with an odds ratio of 2.3 (95%CI: 1.1-5.3, P = 0.019) for having BD. However, when considering the subsample of non-smokers only, BD and presence of Flavonifractor were no longer associated when adjusted for all possible tests at genus level (Q = 0.6). Presence of Flavonifractor in patients with BD was associated with smoking and female sex, but not with age, waist circumference, exercise level, high-sensitive C-reactive protein, current affective state, subtype of BD, illness duration or psychotropic medication, respectively. CONCLUSION: Flavonifractor, a bacterial genus that may induce oxidative stress and inflammation in its host, was associated with BD. Higher prevalence of smoking among patients with BD contributed to our findings, and it cannot be excluded that findings are influenced by residual confounding.

Experiment 1

Needs review

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks


Location of subjects
Host species Species from which microbiome was sampled (if applicable)
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
bipolar disorder [X]Bipolar affective disorder, unspecified,[X]Bipolar affective disorder, unspecified (disorder),Affective Bipolar Psychosis,Affective Psychosis, Bipolar,Bipolar affective disorder,bipolar affective disorder,Bipolar affective disorder , current episode mixed (disorder),Bipolar affective disorder, current episode depression (disorder),Bipolar affective disorder, manic, unspecified degree,Bipolar affective disorder, mixed, unspecified degree,Bipolar Affective Psychosis,Bipolar Depression,bipolar depression,BIPOLAR DIS,bipolar disease,bipolar disorder,Bipolar disorder (disorder),bipolar disorder manic phase,BIPOLAR DISORDER NOS,Bipolar disorder, NOS,Bipolar disorder, unspecified,Bipolar Disorders,Depression, Bipolar,Depressive-manic psych.,depressive-manic psych.,Disorder, Bipolar,Disorder, Manic,MAFD,major affective disorder,major bipolar affective disorder,Mania,Manias,Manic Bipolar Affective disorder,manic bipolar affective disorder,Manic bipolar I disorder,manic bipolar I disorder,Manic bipolar I disorder (disorder),manic depression,Manic Depressive disorder,manic depressive disorder,MANIC DEPRESSIVE ILLNESS,Manic Depressive Psychosis,MANIC DIS,Manic Disorder,manic disorder,Manic Disorders,Manic State,Manic States,Manic-Depression,manic-depression,Manic-depressive illness,manic-depressive illness,Manic-Depressive Psychoses,Manic-depressive psychosis,manic-depressive psychosis,Manic-depressive syndrome NOS,MDI - Manic-depressive illness,mixed bipolar affective disorder (disorder),mixed bipolar affective disorder, NOS (disorder),mixed bipolar disorder,mixed bipolar I disorder (disorder),Psychoses, Bipolar Affective,Psychoses, Manic Depressive,Psychoses, Manic-Depressive,Psychosis, Bipolar Affective,Psychosis, Manic Depressive,Psychosis, Manic-Depressive,State, Manic,States, Manic,Unspecified bipolar affective disorder,Unspecified bipolar affective disorder (disorder),Unspecified bipolar affective disorder, NOS,Unspecified bipolar affective disorder, NOS (disorder),Unspecified bipolar affective disorder, unspecified,Unspecified bipolar affective disorder, unspecified (disorder)
Group 0 name Corresponds to the control (unexposed) group for case-control studies
healthy controls
Group 1 name Corresponds to the case (exposed) group for case-control studies
Group 0 sample size Number of subjects in the control (unexposed) group
Group 1 sample size Number of subjects in the case (exposed) group

Lab analysis

Sequencing type
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance

Statistical Analysis

Statistical test
Fisher's Exact Test
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
sex, age, smoking behavior, waist circumference, physical activity

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness

Signature 1

Needs review

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): WikiWorks

Source: tabl2, figure3

Description: gut microbiota composition in patients with newly diagnosed bipolar and unaffected first-degree relatives

Abundance in Group 1: increased abundance in bipolar

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Revision editor(s): WikiWorks