Alteration in gut mycobiota of patients with polycystic ovary syndrome/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Peace Sandy on 2024-4-8
Curated date: 2024/03/25
Curator: Linda Uchenwoke
Revision editor(s): Linda Uchenwoke, Peace Sandy, Svetlana up
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Polycystic ovary syndrome Cystic disease of ovaries,hyperandrogenemia,Multicystic ovaries,multicystic ovaries,Ovarian Degeneration, Sclerocystic,Ovarian Syndrome, Polycystic,Ovarian Syndromes, Polycystic,Ovaries, Sclerocystic,Ovary Syndrome, Polycystic,Ovary, Sclerocystic,PCO - Polycystic ovaries,Pco1,PCOD - Polycystic ovarian disease,PCOS,Pcos,PCOS - Polycystic ovarian syndrome,PCOS1,Polycystic ovarian disease,polycystic ovarian disease,Polycystic ovarian syndrome,Polycystic ovaries,polycystic ovaries,Polycystic ovaries (disorder),polycystic ovary,polycystic ovary syndrome,polycystic ovary syndrome 1,Sclerocystic Ovarian Degeneration,Sclerocystic Ovaries,Sclerocystic Ovary,Sclerocystic Ovary Syndrome,Stein Leventhal Syndrome,Stein-Leventhal synd.,Stein-Leventhal Syndrome,Stein-Leventhal syndrome,Syndrome, Polycystic Ovary,Syndrome, Stein-Leventhal,Polycystic ovary syndrome
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Polycystic ovary syndrome (PCOS) patients
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Women with PCOS diagnosed according to the 2003 Rotterdam criteria.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 17
- Group 1 sample size Number of subjects in the case (exposed) group
- 17
Lab analysis
- Sequencing type
- PCR
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 4
- Matched on Factors on which subjects have been matched on in a case-control study
- age
Alpha Diversity
- Pielou Quantifies how equal the community is numerically
- decreased
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
- Chao1 Abundance-based estimator of species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- decreased
- Richness Number of species
- decreased
Signature 1
Reviewed Marked as Reviewed by Peace Sandy on 2024-4-8
Source: Figure 7
Description: Differences in microbial genera identified by LEfSe analysis.
Abundance in Group 1: increased abundance in Polycystic ovary syndrome (PCOS) patients
| NCBI | Quality Control | Links |
|---|---|---|
| Ascomycota | ||
| Lentinula | ||
| Lentinula edodes | ||
| Marasmiaceae | ||
| Saccharomyces | ||
| Saccharomyces cerevisiae | ||
| Saccharomycetaceae | ||
| Saccharomycetales | ||
| Saccharomycetes | ||
| unclassified Saccharomyces |
Revision editor(s): Linda Uchenwoke
Signature 2
Reviewed Marked as Reviewed by Peace Sandy on 2024-4-8
Source: Figure 7
Description: Differences in microbial genera identified by LEfSe analysis.
Abundance in Group 1: decreased abundance in Polycystic ovary syndrome (PCOS) patients
| NCBI | Quality Control | Links |
|---|---|---|
| Aspergillus | ||
| Cryptocellus magnus | ||
| Eurotiales | ||
| Trichocomaceae | ||
| Tremellomycetes | ||
| Basidiomycota |
Revision editor(s): Linda Uchenwoke
