Airway Microbiome and Serum Metabolomics Analysis Identify Differential Candidate Biomarkers in Allergic Rhinitis/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2024-4-8
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Inferior nasal concha Concha nasalis inferior,Concha nasi inferior,Inferior concha,Inferior nasal turbinate,Inferior nasal turbinate bone,Inferior turbinate,Inferior turbinated,Maxilloturbinal,Inferior nasal concha,inferior nasal concha
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Allergic rhinitis allergic form of rhinitis,allergic rhinitis,Alrh,atopic rhinitis,non-seasonal allergic rhinitis,Perenial allergic rhinitis,perennial allergic rhinitis,pollenosis,seasonal allergic rhinitis,Allergic rhinitis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy controls (HC)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Allergic rhinitis (AR)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients with allergic rhinitis (AR)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 15
- Group 1 sample size Number of subjects in the case (exposed) group
- 28
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Ion Torrent
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age, sex
Alpha Diversity
- Chao1 Abundance-based estimator of species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
- Richness Number of species
- unchanged
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2024-4-8
Source: Figure 3. C, D.
Description: The distribution of taxa in phylum and genus levels of AR and HC groups. (C) the statistical results of top 10 phyla. (D) the statistical results of top 35 genera.
Abundance in Group 1: increased abundance in Allergic rhinitis (AR)
Revision editor(s): Omojokunoluwatomisin, Ayibatari
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2024-4-8
Source: Figure 3 D.
Description: The distribution of taxa in phylum and genus levels of AR and HC groups. (D) the statistical results of top 35 genera.
Abundance in Group 1: decreased abundance in Allergic rhinitis (AR)
| NCBI | Quality Control | Links |
|---|---|---|
| Roseateles |
Revision editor(s): Ayibatari, Svetlana up
