Signatures within the esophageal microbiome are associated with host genetics, age, and disease/Experiment 9
From BugSigDB
Needs review
Subjects
- Location of subjects
- Australia
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Esophagus Gullet,Oesophagus,Esophagus,esophagus
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Barrett's esophagus (ulcerative esophagitis) or (Barrett's esophagus),adenocarcinoma of esophagus,Barrett Epithelium,Barrett Esophagus,Barrett esophagus,Barrett metaplasia,Barrett Syndrome,Barrett's esophagus,Barrett's esophagus (disorder),Barrett's esophagus (disorder) [Ambiguous],Barrett's esophagus with esophagitis,Barrett's esophagus with esophagitis (disorder),Barrett's oesophagus,Barrett's Syndrome,Barrett's ulcer of esophagus,Barrett's ulcer of esophagus (disorder),Barretts Esophagus,Barretts syndrome,BE,cello,CLE,columnar epithelial-lined Lower esophagus,columnar-lined esophagus,Epithelium, Barrett,Esophagus, Barrett,Esophagus, Barrett's,Syndrome, Barrett,Syndrome, Barrett's,ulcerative esophagitis,barrett's esophagus
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Normal
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Barrett’s Esophagus (BE)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- This group consists of patients with Barrett’s Esophagus
- Group 0 sample size Number of subjects in the control (unexposed) group
- 59
- Group 1 sample size Number of subjects in the case (exposed) group
- 12
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 2 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Signature 1
Needs review
Source: Additional file 3, page 4
Description: The differences across disease subgroups using LEfSe analysis (16S rRNA amplicon data).
Abundance in Group 1: increased abundance in Barrett’s Esophagus (BE)
| NCBI | Quality Control | Links |
|---|---|---|
| Leptotrichia | ||
| Capnocytophaga |
Revision editor(s): Fiddyhamma
