Mild atopic dermatitis is characterized by increase in non-staphylococcus pathobionts and loss of specific species/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2024-11-6
Subjects
- Location of subjects
- Belgium
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Skin of body Entire integument,Entire skin,Integument,Integumental organ,Pelt,Skin,Skin organ,Skin of body,skin of body
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Dermatitis inflammation of skin,inflammation of the skin,inflammation of zone of skin,inflammatory skin disease,skin inflammation,zone of skin inflammation,Dermatitis,dermatitis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- mild atopic dermatitis (AD)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants diagnosed with mild atopic dermatitis (AD). This group specifically includes individuals who exhibit mild lesions characterized by limited symptoms.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 49
- Group 1 sample size Number of subjects in the case (exposed) group
- 28
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- N/A
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- log transformation
- Statistical test
- MaAsLin2
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2024-11-6
Source: Figure 3a
Description: Differential abundance analysis for mild AD patients compared to healthy participants using Maaslin2
Abundance in Group 1: increased abundance in mild atopic dermatitis (AD)
Revision editor(s): Joiejoie, Aleru Divine
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2024-11-6
Source: Figure 3a
Description: Differential abundance analysis for mild AD patients compared to healthy participants using Maaslin2
Abundance in Group 1: decreased abundance in mild atopic dermatitis (AD)
Revision editor(s): Joiejoie, Aleru Divine
