Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations/Experiment 2
Subjects
- Location of subjects
- Canada
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Breastfeeding duration Breastfeeding duration,breastfeeding duration
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Increasing Exclusive Breast Feeding (EBF)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Reduced exclusivity of beast feeding to none breastfeeding
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Introducing other foods or liquids while still breastfeeding
- Group 0 sample size Number of subjects in the control (unexposed) group
- 86
- Group 1 sample size Number of subjects in the case (exposed) group
- 48
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Random Forest Analysis
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.005
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
- Chao1 Abundance-based estimator of species richness
- increased
Signature 1
Source: Table 3, Table 2
Description: Meta-analysis of five studies that included a non-breastfeeding group for gut bacterial taxa with trend in relative abundance across exclusive breastfeeding, nonexclusive breastfeeding and non breastfeeding groups.
Abundance in Group 1: increased abundance in Reduced exclusivity of beast feeding to none breastfeeding
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia | ||
| Bacillota | ||
| Bacteroidia | ||
| Blautia | ||
| Coprococcus | ||
| Eubacterium | ||
| Verrucomicrobiota | ||
| Bacteroides | ||
| Clostridium | ||
| Megasphaera | ||
| Veillonella | ||
| Eubacterium sp. |
Revision editor(s): Shulamite, Rahila, Peace Sandy
Signature 2
Source: Table 3, Table 2
Description: Meta-analysis of five studies that included a non-breastfeeding group for gut bacterial taxa with trend in relative abundance across exclusive breastfeeding, nonexclusive breastfeeding and non breastfeeding groups.
Abundance in Group 1: decreased abundance in Reduced exclusivity of beast feeding to none breastfeeding
| NCBI | Quality Control | Links |
|---|---|---|
| Haemophilus | ||
| Staphylococcus |
Revision editor(s): Shulamite, Peace Sandy
