Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes/Experiment 24
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2024-11-25
Subjects
- Location of subjects
- Denmark
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Insulin sensitivity measurement insulin sensitivity test,Insulin sensitivity measurement,insulin sensitivity measurement
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Lower Tertile (low insulin sensitivity index)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Upper Tertile (high insulin sensitivity index)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) with higher maternal insulin sensitivity index.
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 2 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V1-V2
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- raw counts
- Statistical test
- DESeq2
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- body mass index
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2024-11-18
Source: Table S9
Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (insulin sensitivity index), adjusted for pre-pregnancy BMI.
Abundance in Group 1: increased abundance in Upper Tertile (high insulin sensitivity index)
| NCBI | Quality Control | Links |
|---|---|---|
| Streptococcus |
Revision editor(s): AishatBolarinwa, Aleru Divine
