Gut microbiota-derived gamma-aminobutyric acid improves host appetite by inhibiting satiety hormone secretion/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2024-10-26
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Oryctolagus cuniculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Material entity in digestive tract Digestive tract contents,Ingested material entity,Material entity in digestive tract,material entity in digestive tract
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Eating behaviour Eating behaviour,eating behaviour
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low feed intake
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High feed intake
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- The six rabbits with the highest feed intake from a group of 100 rabbits.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 6
- Group 1 sample size Number of subjects in the case (exposed) group
- 6
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V1-V9
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- PacBio RS
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.01
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 3
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2024-10-26
Source: Fig 4H
Description: Differences in gut microbiota at genus level between High Feed Intake and Low Feed Intake rabbit groups.
Abundance in Group 1: increased abundance in High feed intake
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides | ||
| Mediterranea | ||
| unclassified Actinomycetota | ||
| unclassified Coriobacteriia |
Revision editor(s): YokoC, Scholastica
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2024-10-26
Source: Fig 4H
Description: Differences in gut microbiota at genus level between High Feed Intake and Low Feed Intake rabbit groups.
Abundance in Group 1: decreased abundance in High feed intake
| NCBI | Quality Control | Links |
|---|---|---|
| Acetivibrio | ||
| Breznakia | ||
| Spiroplasma | ||
| unclassified Erysipelotrichaceae | ||
| unclassified Gammaproteobacteria | ||
| unclassified Mollicutes | ||
| unclassified Oscillospiraceae |
Revision editor(s): YokoC, Rahila, Scholastica
