Gut microbiota-derived gamma-aminobutyric acid improves host appetite by inhibiting satiety hormone secretion/Experiment 2

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Reviewed Marked as Reviewed by Svetlana up on 2024-10-26

Curated date: 2024/10/18

Curator: YokoC

Revision editor(s): YokoC

Subjects

Location of subjects

China

Host species Species from which microbiome was sampled. Contact us to have more species added.

Oryctolagus cuniculus

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology

Material entity in digestive tract Digestive tract contents,Ingested material entity,Material entity in digestive tract,material entity in digestive tract

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Eating behaviour Eating behaviour,eating behaviour

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Low feed intake

Group 1 name Corresponds to the case (exposed) group for case-control studies

High feed intake

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

The six rabbits with the highest feed intake from a group of 100 rabbits.

Group 0 sample size Number of subjects in the control (unexposed) group

6

Group 1 sample size Number of subjects in the case (exposed) group

6

Lab analysis

Sequencing type

16S

16S variable region One or more hypervariable region(s) of the bacterial 16S gene

V1-V9

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance

PacBio RS

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).

relative abundances

Statistical test

Mann-Whitney (Wilcoxon)

Significance threshold p-value or FDR threshold used for differential abundance testing (if any)

0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?

No

Signature 1

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Reviewed Marked as Reviewed by Svetlana up on 2024-10-26

Curated date: 2024/10/18

Curator: YokoC

Revision editor(s): YokoC, Scholastica

Source: Fig 4G

Description: Differential analysis at species level in High Feed Intake versus Low Feed Intake rabbit groups.

Abundance in Group 1: increased abundance in High feed intake

NCBI	Quality Control	Links
Bacteroides caccae
Bacteroides rodentium

Revision editor(s): YokoC, Scholastica