The human microbiota is associated with cardiometabolic risk across the epidemiologic transition
-
Quality control
- Retracted paper
- Contamination issues suspected
- Batch effect issues suspected
- Uncontrolled confounding suspected
- Results are suspect (various reasons)
- Tags applied
Experiment 1
Subjects
- Location of subjects
- Ghana
- South Africa
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Risk factor Factor, Risk,Factors, Risk,Risk Factors,Risk factor,risk factor
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-CMD
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- CMD
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants in the CMD group had Cardiometabolic Risk (CM) risk defined as at least 3 CM risk factors from five: waist circumference, elevated blood pressure, elevated blood fasting glucose, elevated triglyceride and low HDL concentration in USA, RSA, and Ghana
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- ANCOM
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, sex, Confounders controlled for: "country" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.country
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
Signature 1
Source: Figure 2D
Description: Specific gut bacterial taxa are differentially abundant (in relative terms) between study sites with and without elevated CM risk (only significantly differential exact sequence variants (ESVs) with relative abundance ≥ 1% in at least one group shown.
Abundance in Group 1: increased abundance in CMD
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides | ||
| Lachnospiraceae |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure 2D
Description: Specific gut bacterial taxa are differentially abundant (in relative terms) between study sites with and without elevated CM risk (only significantly differential exact sequence variants (ESVs) with relative abundance ≥ 1% in at least one group shown.
Abundance in Group 1: decreased abundance in CMD
| NCBI | Quality Control | Links |
|---|---|---|
| Streptococcaceae | ||
| Prevotella | ||
| Clostridiaceae |
Revision editor(s): Aleru Divine
Experiment 2
Subjects
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
Lab analysis
Statistical Analysis
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
Signature 1
Source: Figure 3C
Description: Specific oral bacterial taxa are differentially abundant (in relative terms) between study sites with and without elevated CM risk (only significantly differential exact sequence variants (ESVs) with relative abundance ≥ 1% in at least one group shown.
Abundance in Group 1: increased abundance in CMD
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella | ||
| Rothia | ||
| Streptococcus | ||
| Veillonella |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure 3C
Description: Specific oral bacterial taxa are differentially abundant (in relative terms) between study sites with and without elevated CM risk (only significantly differential exact sequence variants (ESVs) with relative abundance ≥ 1% in at least one group shown.
Abundance in Group 1: decreased abundance in CMD
| NCBI | Quality Control | Links |
|---|---|---|
| Neisseria | ||
| Fusobacterium | ||
| Neisseria sp. | ||
| Haemophilus | ||
| Rothia |
Revision editor(s): Aleru Divine
Experiment 3
Subjects
- Location of subjects
- Jamaica
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hyperglycemia High blood glucose,High blood sugar,Hyperglycemia,hyperglycemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hyperglycemia
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hyperglycemia
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants from Jamaica with elevated fasting blood glucose.
Lab analysis
Statistical Analysis
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
Signature 1
Source: Figure S7b
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between hyperglycemic and non-hyperglycemic participants from Jamaica.
Abundance in Group 1: increased abundance in Hyperglycemia
| NCBI | Quality Control | Links |
|---|---|---|
| Oscillospiraceae |
Revision editor(s): Aleru Divine
Experiment 4
Subjects
- Location of subjects
- Ghana
- Jamaica
- South Africa
- United States of America
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Waist circumference Waist circumference,waist circumference
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low waist circumference
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High waist circumference
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Male participants from all countries (Jamaica, Ghana, South Africa and United States of America) with high waist circumference.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S6a
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between low waist and high waist circumference in male participants in all countries.
Abundance in Group 1: increased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Blautia | ||
| Coprococcus | ||
| Coprococcus sp. | ||
| Lachnospiraceae | ||
| Streptococcus |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S6a
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between low waist and high waist circumference in male participants in all countries.
Abundance in Group 1: decreased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Enterobacteriaceae | ||
| Prevotella |
Revision editor(s): Aleru Divine
Experiment 5
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All(male and female) participants from all countries (Jamaica, Ghana, South Africa and United States of America) with high waist circumference.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S6b
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between low waist and high waist circumference in all participants in all countries.
Abundance in Group 1: increased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Roseburia |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S6b
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between low waist and high waist circumference in all participants in all countries.
Abundance in Group 1: decreased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Clostridiaceae | ||
| Clostridiaceae bacterium | ||
| Enterobacteriaceae | ||
| Peptostreptococcaceae | ||
| Prevotella |
Revision editor(s): Aleru Divine
Experiment 6
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Female participants from all countries (Jamaica, Ghana, South Africa and United States of America) with high waist circumference.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S6c
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between low waist and high waist circumference in female participants in all countries.
Abundance in Group 1: increased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Roseburia |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S6c
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between low waist and high waist circumference in female participants in all countries.
Abundance in Group 1: decreased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Clostridiaceae | ||
| Clostridiaceae bacterium | ||
| Enterobacteriaceae | ||
| Oscillospira |
Revision editor(s): Aleru Divine
Experiment 7
Subjects
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hypertension (hypertensive disease) or (hypertension),[X]Hypertensive diseases,[X]Hypertensive diseases (disorder),Blood Pressure, High,blood pressure, high,blood pressure, increased,Blood Pressures, High,High Blood Pressure,high blood pressure,High blood pressure (& [essential hypertension]),High Blood Pressures,HTN,HTN - hypertension,hyperpiesia,hypertension,hypertension NOS,HYPERTENSIVE DISEASE,hypertensive disease,Hypertensive disease (disorder),hypertensive disease NOS,Hypertensive disease NOS (disorder),hypertensive disorder,increased blood pressure,pressure, high blood,SURG COMP - HYPERTENSION,vascular hypertensive disorder,Hypertension
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hypertension
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertension
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All(male and female) participants from all countries (Jamaica, Ghana, South Africa and United States of America) with elevated blood pressure (hypertention).
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S6d
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive participants in all countries.
Abundance in Group 1: decreased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Enterobacteriaceae |
Revision editor(s): Aleru Divine
Experiment 8
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Male participants from all countries (Jamaica, Ghana, South Africa and United States of America) with elevated blood pressure (Hypertension).
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S6e
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive male participants in all countries.
Abundance in Group 1: decreased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Faecalibacterium |
Revision editor(s): Aleru Divine
Experiment 9
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Female participants from all countries (Jamaica, Ghana, South Africa and United States of America) with elevated blood pressure (hypertension).
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S6f
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive female participants in all countries.
Abundance in Group 1: increased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Clostridiaceae |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S6f
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive female participants in all countries.
Abundance in Group 1: decreased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides | ||
| Enterobacteriaceae | ||
| Oscillospira | ||
| Parabacteroides | ||
| Peptostreptococcaceae |
Revision editor(s): Aleru Divine
Experiment 10
Subjects
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hyperglycemia High blood glucose,High blood sugar,Hyperglycemia,hyperglycemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hyperglycemia
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hyperglycemia
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All(male and female) participants from all countries (Jamaica, Ghana, South Africa and United States of America) with elevated fasted blood glucose (Hyperglycemia).
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S6g
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between non-hyperglycemic and hyperglycemic participants in all countries.
Abundance in Group 1: increased abundance in Hyperglycemia
| NCBI | Quality Control | Links |
|---|---|---|
| Enterobacteriaceae |
Revision editor(s): Aleru Divine
Experiment 11
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Female participants from all countries (Jamaica, Ghana, South Africa and United States of America) with elevated fasted blood glucose (hyperglycemia)
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S6h
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between non-hyperglycemic and hyperglycemic female participants in all countries.
Abundance in Group 1: increased abundance in Hyperglycemia
| NCBI | Quality Control | Links |
|---|---|---|
| Enterobacteriaceae |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S6h
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between non-hyperglycemic and hyperglycemic female participants in all countries.
Abundance in Group 1: decreased abundance in Hyperglycemia
| NCBI | Quality Control | Links |
|---|---|---|
| Erysipelotrichaceae | ||
| Veillonellaceae |
Revision editor(s): Aleru Divine
Experiment 12
Subjects
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hypertriglyceridemia hypertriglyceridemia,hypertriglyceridemia (disease),Hypertriglyceridemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hypertriglyceridemia
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertriglyceridemia
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All(male and female) participants from all countries (Jamaica, Ghana, South Africa and United States of America) with Hypertriglyceridemia.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S6i
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between non-hypertriglyceridemic and hypertriglyceridemic participants in all countries.
Abundance in Group 1: decreased abundance in Hypertriglyceridemia
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella |
Revision editor(s): Aleru Divine
Experiment 13
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Female participants from all countries (Jamaica, Ghana, South Africa and United States of America) with Hypertriglyceridemia.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S6j
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between non-hypertriglyceridemic and hypertriglyceridemic female participants in all countries.
Abundance in Group 1: increased abundance in Hypertriglyceridemia
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides | ||
| Bacteroides sp. | ||
| Coprococcus | ||
| Parabacteroides |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S6j
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between non-hypertriglyceridemic and hypertriglyceridemic female participants in all countries.
Abundance in Group 1: decreased abundance in Hypertriglyceridemia
| NCBI | Quality Control | Links |
|---|---|---|
| Catenibacterium | ||
| Clostridiaceae | ||
| Oscillospira | ||
| Prevotella |
Revision editor(s): Aleru Divine
Experiment 14
Subjects
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- HDL cholesterol alpha Lipoprotein Cholesterol,alpha Lipoproteins,alpha-1 Lipoprotein,alpha-Lipoprotein Cholesterol,alpha-Lipoproteins,Cholesterol, alpha-Lipoprotein,Cholesterol, HDL,Cholesterol, HDL2,Cholesterol, HDL3,HDL Lipoproteins,HDL(2) Cholesterol,HDL(3) Cholesterol,HDL2 Cholesterol,HDL3 Cholesterol,Heavy Lipoproteins,High Density Lipoprotein Cholesterol,High Density Lipoproteins,high-density lipoprotein cholesterol,High-Density Lipoproteins,Lipoproteins, HDL,Lipoproteins, Heavy,Lipoproteins, High-Density,HDL cholesterol,hDL cholesterol
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- HIGH high-density lipoprotein (HDL)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- LOW high-density lipoprotein (HDL)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All(male and female) participants from all countries (Jamaica, Ghana, South Africa and United States of America) with LOW high-density lipoprotein (HDL) concentration.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S6k
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between low HDL and high HDL levels in all participants in all countries.
Abundance in Group 1: increased abundance in LOW high-density lipoprotein (HDL)
| NCBI | Quality Control | Links |
|---|---|---|
| Enterobacteriaceae |
Revision editor(s): Aleru Divine
Experiment 15
Subjects
- Location of subjects
- Ghana
- South Africa
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Waist circumference Waist circumference,waist circumference
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low waist circumference
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High waist circumference
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All participants from Ghana and South Africa with high waist circumference.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S7a
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in participants from Ghana and South Africa.
Abundance in Group 1: increased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Dialister |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S7a
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in participants from Ghana and South Africa.
Abundance in Group 1: decreased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Blautia |
Revision editor(s): Aleru Divine
Experiment 16
Subjects
- Location of subjects
- South Africa
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hypertriglyceridemia hypertriglyceridemia,hypertriglyceridemia (disease),Hypertriglyceridemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hypertriglyceridemia
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertriglyceridemia
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants from South Africa who had hypertriglyceridemia.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S7c
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between non-hyperglyceridemic and hyperglyceridemic participants from South Africa.
Abundance in Group 1: decreased abundance in Hypertriglyceridemia
| NCBI | Quality Control | Links |
|---|---|---|
| Oscillospira |
Revision editor(s): Aleru Divine
Experiment 17
Subjects
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- HDL cholesterol alpha Lipoprotein Cholesterol,alpha Lipoproteins,alpha-1 Lipoprotein,alpha-Lipoprotein Cholesterol,alpha-Lipoproteins,Cholesterol, alpha-Lipoprotein,Cholesterol, HDL,Cholesterol, HDL2,Cholesterol, HDL3,HDL Lipoproteins,HDL(2) Cholesterol,HDL(3) Cholesterol,HDL2 Cholesterol,HDL3 Cholesterol,Heavy Lipoproteins,High Density Lipoprotein Cholesterol,High Density Lipoproteins,high-density lipoprotein cholesterol,High-Density Lipoproteins,Lipoproteins, HDL,Lipoproteins, Heavy,Lipoproteins, High-Density,HDL cholesterol,hDL cholesterol
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- HIGH high-density lipoprotein (HDL)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- LOW high-density lipoprotein (HDL)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All participants from South Africa with LOW high-density lipoprotein (HDL) concentration.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S7d
Description: Specific gut bacterial exact sequences variances (ESV) are differentially abundant between low HDL and high HDL levels in participants from South Africa.
Abundance in Group 1: increased abundance in LOW high-density lipoprotein (HDL)
| NCBI | Quality Control | Links |
|---|---|---|
| Megasphaera |
Revision editor(s): Aleru Divine
Experiment 18
Subjects
- Location of subjects
- Ghana
- Jamaica
- South Africa
- United States of America
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Waist circumference Waist circumference,waist circumference
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low waist circumference
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High waist circumference
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All participants from all countries (Jamaica, Ghana, South Africa and United States of America) with high waist circumference.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S18a
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in participants from all countries.
Abundance in Group 1: increased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella | ||
| Streptococcus | ||
| Veillonella |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S18a
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in participants from all countries.
Abundance in Group 1: decreased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Rothia | ||
| Prevotella |
Revision editor(s): Aleru Divine
Experiment 19
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Male participants from all countries (Jamaica, Ghana, South Africa and United States of America) with high waist circumference.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S18b
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in male participants from all countries.
Abundance in Group 1: increased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella | ||
| Veillonella | ||
| Streptococcus |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S18b
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in male participants from all countries.
Abundance in Group 1: decreased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Neisseria | ||
| Neisseria sp. |
Revision editor(s): Aleru Divine
Experiment 20
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Female participants from all countries (Jamaica, Ghana, South Africa and United States of America) with high waist circumference.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S18c
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in female participants from all countries.
Abundance in Group 1: increased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Streptococcus | ||
| Veillonella | ||
| Prevotella |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S18c
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in female participants from all countries.
Abundance in Group 1: decreased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Rothia |
Revision editor(s): Aleru Divine
Experiment 21
Subjects
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hypertension (hypertensive disease) or (hypertension),[X]Hypertensive diseases,[X]Hypertensive diseases (disorder),Blood Pressure, High,blood pressure, high,blood pressure, increased,Blood Pressures, High,High Blood Pressure,high blood pressure,High blood pressure (& [essential hypertension]),High Blood Pressures,HTN,HTN - hypertension,hyperpiesia,hypertension,hypertension NOS,HYPERTENSIVE DISEASE,hypertensive disease,Hypertensive disease (disorder),hypertensive disease NOS,Hypertensive disease NOS (disorder),hypertensive disorder,increased blood pressure,pressure, high blood,SURG COMP - HYPERTENSION,vascular hypertensive disorder,Hypertension
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hypertension
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertension
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All participants from all countries (Jamaica, Ghana, South Africa and United States of America) with elevated blood pressure (hypertension).
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S18d
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive participants in all countries.
Abundance in Group 1: increased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella | ||
| Veillonella |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S18d
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive participants in all countries.
Abundance in Group 1: decreased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella | ||
| Rothia |
Revision editor(s): Aleru Divine
Experiment 22
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Male participants from all countries (Jamaica, Ghana, South Africa and United States of America) with elevated blood pressure (hypertension).
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S18e
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive male participants in all countries.
Abundance in Group 1: increased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Veillonella |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S18e
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive male participants in all countries.
Abundance in Group 1: decreased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Neisseria |
Revision editor(s): Aleru Divine
Experiment 23
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Female participants from all countries (Jamaica, Ghana, South Africa and United States of America) with elevated blood pressure (hypertension).
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S18f
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive female participants in all countries.
Abundance in Group 1: increased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S18f
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive female participants in all countries.
Abundance in Group 1: decreased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Rothia |
Revision editor(s): Aleru Divine
Experiment 24
Subjects
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hypertriglyceridemia hypertriglyceridemia,hypertriglyceridemia (disease),Hypertriglyceridemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-Hypertriglyceridemia
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertriglyceridemia
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Female participants from all countries (Jamaica, Ghana, South Africa and United States of America) with hypertriglyceridemia.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S18g
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between non-hypertriglyceridemic and hypertriglyceridemic female participants in all countries.
Abundance in Group 1: increased abundance in Hypertriglyceridemia
| NCBI | Quality Control | Links |
|---|---|---|
| Veillonella |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S18g
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between non-hypertriglyceridemic and hypertriglyceridemic female participants in all countries.
Abundance in Group 1: decreased abundance in Hypertriglyceridemia
| NCBI | Quality Control | Links |
|---|---|---|
| Neisseria |
Revision editor(s): Aleru Divine
Experiment 25
Subjects
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- HDL cholesterol alpha Lipoprotein Cholesterol,alpha Lipoproteins,alpha-1 Lipoprotein,alpha-Lipoprotein Cholesterol,alpha-Lipoproteins,Cholesterol, alpha-Lipoprotein,Cholesterol, HDL,Cholesterol, HDL2,Cholesterol, HDL3,HDL Lipoproteins,HDL(2) Cholesterol,HDL(3) Cholesterol,HDL2 Cholesterol,HDL3 Cholesterol,Heavy Lipoproteins,High Density Lipoprotein Cholesterol,High Density Lipoproteins,high-density lipoprotein cholesterol,High-Density Lipoproteins,Lipoproteins, HDL,Lipoproteins, Heavy,Lipoproteins, High-Density,HDL cholesterol,hDL cholesterol
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- HIGH high-density lipoprotein (HDL)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- LOW high-density lipoprotein (HDL)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Female participants from all countries (Jamaica, Ghana, South Africa and United States of America) with LOW high-density lipoprotein (HDL) concentration.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S18h
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between low HDL and high HDL levels in female participants from all countries.
Abundance in Group 1: increased abundance in LOW high-density lipoprotein (HDL)
| NCBI | Quality Control | Links |
|---|---|---|
| Neisseria | ||
| Prevotella |
Revision editor(s): Aleru Divine
Experiment 26
Subjects
- Location of subjects
- Ghana
- South Africa
- United States of America
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Waist circumference Waist circumference,waist circumference
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low waist circumference
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High waist circumference
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All participants from Ghana, South Africa and United States of America with high waist circumference.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S19a
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in all participants from Ghana, South Africa and the United States of America.
Abundance in Group 1: increased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Streptococcus | ||
| Streptococcus sp. | ||
| Prevotella | ||
| Haemophilus | ||
| Neisseria |
Revision editor(s): Aleru Divine
Signature 2
Source: Figure S19a
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in all participants from Ghana, South Africa and the United States of America.
Abundance in Group 1: decreased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Porphyromonas |
Revision editor(s): Aleru Divine
Experiment 27
Subjects
- Location of subjects
- United States of America
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hyperglycemia High blood glucose,High blood sugar,Hyperglycemia,hyperglycemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hyperglycemia
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hyperglycemia
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All participants from all countries the United States of America with elevated fasting plasma glucose (hyperglycemia)
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S19b
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between hyperglycemic and non-hyperglycemic participants from the United States of America.
Abundance in Group 1: decreased abundance in Hyperglycemia
| NCBI | Quality Control | Links |
|---|---|---|
| Haemophilus |
Revision editor(s): Aleru Divine
Experiment 28
Subjects
- Location of subjects
- Ghana
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hypertriglyceridemia hypertriglyceridemia,hypertriglyceridemia (disease),Hypertriglyceridemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hypertriglyceridemia
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertriglyceridemia
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants from Ghana with hypertriglyceridemia.
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S19c
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between non-hypertriglyceridemic and hypertriglyceridemic female participants from Ghana.
Abundance in Group 1: increased abundance in Hypertriglyceridemia
| NCBI | Quality Control | Links |
|---|---|---|
| Pasteurellaceae |
Revision editor(s): Aleru Divine
Contents
- 1 Experiment 1
- 2 Experiment 2
- 3 Experiment 3
- 4 Experiment 4
- 5 Experiment 5
- 6 Experiment 6
- 7 Experiment 7
- 8 Experiment 8
- 9 Experiment 9
- 10 Experiment 10
- 11 Experiment 11
- 12 Experiment 12
- 13 Experiment 13
- 14 Experiment 14
- 15 Experiment 15
- 16 Experiment 16
- 17 Experiment 17
- 18 Experiment 18
- 19 Experiment 19
- 20 Experiment 20
- 21 Experiment 21
- 22 Experiment 22
- 23 Experiment 23
- 24 Experiment 24
- 25 Experiment 25
- 26 Experiment 26
- 27 Experiment 27
- 28 Experiment 28
