Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women/Experiment 1
From BugSigDB
Needs review
Subjects
- Location of subjects
- Ghana
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Obesity Adiposis,Adiposity,Obese,Obese (finding),obesity,Obesity (disorder),Obesity [Ambiguous],obesity disease,obesity disorder,Obesity NOS,Obesity, unspecified,Overweight and obesity,Obesity
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Obese Ghanaians(GO) + Obese Americans(UO) + Lean Americans(UL)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Lean Ghanaians (GL)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants in the Lean Ghanaians (GL) group were women from Ghana with body mass index (BMI) < 25 kg/m2
- Group 0 sample size Number of subjects in the control (unexposed) group
- 71
- Group 1 sample size Number of subjects in the case (exposed) group
- 29
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- raw counts
- Statistical test
- Linear Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age
Signature 1
Needs review
Source: Figure 3F and Table S4
Description: Fold change difference of the average abundance of all phenotypic differences (i.e., African American women and obese Ghanaians) versus lean Ghanaians.
Abundance in Group 1: increased abundance in Lean Ghanaians (GL)
Revision editor(s): Aleru Divine
Signature 2
Needs review
Source: Figure 3F and Table S4
Description: Fold change difference of the average abundance of all phenotypic differences (i.e., African American women and obese Ghanaians) versus lean Ghanaians.
Abundance in Group 1: decreased abundance in Lean Ghanaians (GL)
Revision editor(s): Aleru Divine
