A signature of Prevotella copri and Faecalibacterium prausnitzii depletion, and a link with bacterial glutamate degradation in the Kenyan colorectal cancer patients/Experiment 2
From BugSigDB
Needs review
Subjects
- Location of subjects
- Kenya
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Colon Hindgut,Large bowel,Posterior intestine,Colon,colon
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Colorectal cancer cancer of colorectum,cancer of large bowel,cancer of large intestine,cancer of the large bowel,colon cancer,colorectal cancer,colorectum cancer,CRC,large intestine cancer,malignant colorectal neoplasm,malignant colorectal tumor,malignant colorectum neoplasm,malignant large bowel neoplasm,malignant large bowel tumor,malignant large intestine neoplasm,malignant large intestine tumor,malignant neoplasm of colorectum,malignant neoplasm of large bowel,malignant neoplasm of large intestine,malignant neoplasm of the large bowel,malignant neoplasm of the large intestine,malignant tumor of large bowel,malignant tumor of large intestine,malignant tumor of the large bowel,malignant tumor of the large intestine,Colorectal cancer
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- CRC patients under 40 years of age
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- CRC Patients over 40 years of age
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients with Colorectal Cancer over 40 years of age
- Group 0 sample size Number of subjects in the control (unexposed) group
- 8
- Group 1 sample size Number of subjects in the case (exposed) group
- 10
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 4 weeks
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2.0
Signature 1
Needs review
Source: Figure 3
Description: Bar graph of LEfSe analysis for CRC patients under 40 years of age vs. over 40 years of age.
Abundance in Group 1: increased abundance in CRC Patients over 40 years of age
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides ovatus | ||
| Thomasclavelia ramosa | ||
| [Clostridium] symbiosum |
Revision editor(s): Ifeanyisam
Signature 2
Needs review
Source: Figure 3
Description: Bar graph of LEfSe analysis for CRC patients under 40 years of age vs. over 40 years of age.
Abundance in Group 1: decreased abundance in CRC Patients over 40 years of age
| NCBI | Quality Control | Links |
|---|---|---|
| Segatella copri | ||
| Bacteria | ||
| Oxalobacteraceae | ||
| Ligilactobacillus salivarius | ||
| Herbaspirillum | ||
| Enhydrobacter | ||
| Lysobacteraceae | ||
| Lysobacterales |
Revision editor(s): Ifeanyisam
