Differences in the microbial profiles of early stage endometrial cancers between Black and White women/Experiment 1

EditHistoryDelete

Mark reviewed

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Needs review

Curated date: 2024/11/12

Curator: KateRasheed

Revision editor(s): KateRasheed

Subjects

Location of subjects

United States of America

Host species Species from which microbiome was sampled. Contact us to have more species added.

Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology

Connective tissue Bindegewebe,Portion of connective tissue,Textus connectivus,Connective tissue,connective tissue

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Endometrial cancer cancer of endometrium,endometrial Ca,endometrial cancer,endometrial neoplasm,endometrium cancer,malignant endometrial neoplasm,malignant endometrium neoplasm,malignant neoplasm of endometrium,neoplasm of endometrium,primary malignant neoplasm of endometrium,tumor of endometrium,Endometrial cancer

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Benign uterus

Group 1 name Corresponds to the case (exposed) group for case-control studies

Endometrioid endometrial cancers

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Endometrioid endometrial cancers refers to the early stage endometrial tumors which was majorly found in obese Black women.

Group 0 sample size Number of subjects in the control (unexposed) group

16

Group 1 sample size Number of subjects in the case (exposed) group

95

Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)

3 months

Lab analysis

Sequencing type

16S

16S variable region One or more hypervariable region(s) of the bacterial 16S gene

V1-V3

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance

Ion Torrent

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).

log transformation

Statistical test

Metastats

Significance threshold p-value or FDR threshold used for differential abundance testing (if any)

0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?

Yes

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness

increased

Signature 1

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/12

Curator: KateRasheed

Revision editor(s): KateRasheed

Source: Fig. 1

Description: Differentially abundant taxa between Benign (non-cancerous) and Endometrial cancer(malignant).

Abundance in Group 1: increased abundance in Endometrioid endometrial cancers

NCBI	Quality Control	Links
Flavobacterium
Hyphomicrobium

Revision editor(s): KateRasheed