Large-scale metagenomic analysis of oral microbiomes reveals markers for autism spectrum disorders/Experiment 5
From BugSigDB
Needs review
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Cognitive impairment Abnormality of cognition,Cognitive abnormality,Cognitive defects,Cognitive deficits,Cognitive impairment,Intellectual impairment,cognitive impairment
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low Intelligence Quotients(Low IQ ≤70) by diet
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High Intelligence Quotients(High IQ > 85) by diet
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- High Intelligence Quotients(High IQ) was estimated from parent-reported data by an algorithm developed to estimate with high accuracy cognitive levels in large cohorts of ASD children. High IQ refers to intelligent quotients greater than 85. This was adjusted for picky factor(diet).
- Group 0 sample size Number of subjects in the control (unexposed) group
- 413
- Group 1 sample size Number of subjects in the case (exposed) group
- 784
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- Linear Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.2
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- diet, age, sex
Signature 1
Needs review
Source: Fig. 3C
Description: Differentially abundant taxa in oral samples between Autism Spectrum Disorders children with Low IQ and High IQ after adjusting for diet.
Abundance in Group 1: increased abundance in High Intelligence Quotients(High IQ > 85) by diet
Revision editor(s): KateRasheed
Signature 2
Needs review
Source: Fig. 3C, Supplementary Data 18
Description: Differentially abundant taxa in oral samples between Autism Spectrum Disorders children with Low IQ and High IQ after adjusting for diet.
Abundance in Group 1: decreased abundance in High Intelligence Quotients(High IQ > 85) by diet
Revision editor(s): KateRasheed
