Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota/Experiment 8

From BugSigDB


Needs review

Curated date: 2024/12/13

Curator: AaishahM

Revision editor(s): AaishahM

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Blood Portion of blood,Vertebrate blood,Whole blood,Blood,blood
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Alzheimer's disease [X]Dementia in Alzheimer's disease,[X]Dementia in Alzheimer's disease (disorder),AD,AD - Alzheimer's disease,Alzheimer Dementia,Alzheimer dementia,Alzheimer Dementia, Presenile,ALZHEIMER DIS,Alzheimer Disease,Alzheimer disease,Alzheimer disease, familial,Alzheimer Type Dementia,Alzheimer's,Alzheimer's Dementia,Alzheimer's dementia,Alzheimer's disease,Alzheimer's disease (disorder),Alzheimer's disease, NOS,Alzheimers,Alzheimers Dementia,Alzheimers dementia,ALZHEIMERS DIS,Alzheimers disease,DAT - Dementia Alzheimer's type,Dementia in Alzheimer's disease,Dementia in Alzheimer's disease (disorder),Dementia in Alzheimer's disease, unspecified (disorder),Dementia of the Alzheimer's type,Dementia, Alzheimer Type,Dementia, Presenile,Dementia, Presenile Alzheimer,Disease, Alzheimer,Disease, Alzheimer's,Presenile Alzheimer Dementia,sporadic Alzheimer's disease,alzheimer's disease
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal Controls
Group 1 name Corresponds to the case (exposed) group for case-control studies
Alzheimer's Disease (AD) patients
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patients with Alzheimer's Disease
Group 0 sample size Number of subjects in the control (unexposed) group
30
Group 1 sample size Number of subjects in the case (exposed) group
30

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Linear Regression
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No


Signature 1

Needs review

Curated date: 2024/12/13

Curator: AaishahM

Revision editor(s): AaishahM

Source: Table S2

Description: Differences of the blood microbiota at all levels between AD and normal controls

Abundance in Group 1: increased abundance in Alzheimer's Disease (AD) patients

NCBI Quality ControlLinks
Bacilli
Betaproteobacteria
Gammaproteobacteria
Sphingobacteriia
Bacillales
Burkholderiales
Propionibacteriales
Pseudomonadales
Sphingobacteriales
Comamonadaceae
Hyphomicrobiaceae
Propionibacteriaceae
Pseudomonadaceae
Sphingomonadaceae
Staphylococcaceae
Lysobacteraceae
Acidovorax
Blautia
Escherichia
Glutamicibacter
Legionella
Novosphingobium
Pelagibacterium
Propionibacterium
Pseudomonas
Skermanella
Staphylococcus
Stenotrophomonas
Sulfuritalea
Vibrionimonas

Revision editor(s): AaishahM

Signature 2

Needs review

Curated date: 2024/12/13

Curator: AaishahM

Revision editor(s): AaishahM

Source: Table S2

Description: Differences of the blood microbiota at all levels between AD and normal controls

Abundance in Group 1: decreased abundance in Alzheimer's Disease (AD) patients

NCBI Quality ControlLinks
Actinomycetota
Alphaproteobacteria
Caulobacterales
Micrococcales
Oceanospirillales
Hyphomicrobiales
Rhodobacterales
Rhodospirillales
Alcaligenaceae
Brucellaceae
Caulobacteraceae
Halomonadaceae
Moraxellaceae
Oxalobacteraceae
Phyllobacteriaceae
Paracoccaceae
Rhodospirillaceae
Brevundimonas
Enterobacter
Halomonas
Leucobacter
Methyloversatilis
Nesterenkonia
Ochrobactrum
Psychrobacter
Serratia
Undibacterium

Revision editor(s): AaishahM