Changes in the salivary microbiota of oral leukoplakia and oral cancer/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, ChiomaBlessing

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Oral leukoplakia leukokeratosis,Oral idiopathic keratosis,Oral idiopathic leukoplakia,Oral idiopathic white patch,Oral leucoplakia,Oral leukokeratosis,Oral leukoplasia,Oral white patch,Oral white plaque,Oral leukoplakia,oral leukoplakia
Group 0 name Corresponds to the control (unexposed) group for case-control studies
healthy controls
Group 1 name Corresponds to the case (exposed) group for case-control studies
Oral leukoplakia
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Oral leukoplakia patients
Group 0 sample size Number of subjects in the control (unexposed) group
19
Group 1 sample size Number of subjects in the case (exposed) group
10

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Kruskall-Wallis
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Chao1 Abundance-based estimator of species richness
increased
Simpson Estimator of species richness and species evenness: more weight on species evenness
unchanged

Signature 1

Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09

Curated date: 2021/01/10

Curator: Utsav Patel

Revision editor(s): WikiWorks

Source: Fig 1 & 2

Description: Changes in oral microbiota in oral leukoplakia vs. healthy control: a case-control study

Abundance in Group 1: increased abundance in Oral leukoplakia

NCBI Quality ControlLinks
Haemophilus
Bacillus

Revision editor(s): WikiWorks

Signature 2

Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09

Curated date: 2021/01/10

Curator: Utsav Patel

Revision editor(s): WikiWorks

Source: Fig 1 & 2

Description: Changes in oral microbiota in oral leukoplakia vs. healthy control: a case-control study

Abundance in Group 1: decreased abundance in Oral leukoplakia

NCBI Quality ControlLinks
Streptococcus
Abiotrophia

Revision editor(s): WikiWorks