Changes in the salivary microbiota of oral leukoplakia and oral cancer/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Oral leukoplakia leukokeratosis,Oral idiopathic keratosis,Oral idiopathic leukoplakia,Oral idiopathic white patch,Oral leucoplakia,Oral leukokeratosis,Oral leukoplasia,Oral white patch,Oral white plaque,Oral leukoplakia,oral leukoplakia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Oral leukoplakia
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Oral leukoplakia patients
- Group 0 sample size Number of subjects in the control (unexposed) group
- 19
- Group 1 sample size Number of subjects in the case (exposed) group
- 10
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Kruskall-Wallis
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- increased
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Source: Fig 1 & 2
Description: Changes in oral microbiota in oral leukoplakia vs. healthy control: a case-control study
Abundance in Group 1: increased abundance in Oral leukoplakia
| NCBI | Quality Control | Links |
|---|---|---|
| Haemophilus | ||
| Bacillus |
Revision editor(s): WikiWorks
Signature 2
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Source: Fig 1 & 2
Description: Changes in oral microbiota in oral leukoplakia vs. healthy control: a case-control study
Abundance in Group 1: decreased abundance in Oral leukoplakia
| NCBI | Quality Control | Links |
|---|---|---|
| Streptococcus | ||
| Abiotrophia |
Revision editor(s): WikiWorks
