Profiling the oral microbiomes in patients with Alzheimer's disease/Experiment 6

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Needs review

Curated date: 2024/12/14

Curator:

Revision editor(s):

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Gingival groove Gingival sulcus,Sulcus gingivalis,Tooth-gingiva interface,Gingival groove,gingival groove
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Alzheimer's diseaseAlzheimer's disease

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Early-onset Alzheimer's Disease patients (EAG)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Late-onset Alzheimer's Disease patients (NAG)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patients with late-onset Alzheimer's Disease
Group 0 sample size Number of subjects in the control (unexposed) group
10
Group 1 sample size Number of subjects in the case (exposed) group
16
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
3 months

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
PacBio RS

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Welch's T-Test
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No


Signature 1

Needs review

Curated date: 2024/12/14

Curator: AaishahM

Revision editor(s): AaishahM, WikiWorks

Source: Figure 5b

Description: Differential bacteria in AD patients with different clinical types

Abundance in Group 1: increased abundance in

NCBI Quality ControlLinks
Streptococcus constellatus
Porphyromonas gingivalis
Mogibacterium timidum

Revision editor(s): AaishahM, WikiWorks