Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism/Experiment 2
From BugSigDB
Subjects
- Location of subjects
- Finland
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Pregnancy Gestation,PREGN,Pregnancies,Pregnancy,pregnancy
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Infants
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Women at 27 weeks Pregnant
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Differences in maternal species-level taxonomy and gene-level composition between Infants and Women at 27 weeks pregnant
- Group 0 sample size Number of subjects in the control (unexposed) group
- 74
- Group 1 sample size Number of subjects in the case (exposed) group
- 137
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- prior antibiotic treatment
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- MaAsLin2
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.25
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Source: Figure 2A and Figure 2D
Description: differences in species at gestational week 27
Abundance in Group 1: increased abundance in Women at 27 weeks Pregnant
| NCBI | Quality Control | Links |
|---|---|---|
| Streptococcus parasanguinis | ||
| Streptococcus salivarius | ||
| Bilophila wadsworthia |
Revision editor(s): Miss Lulu
Signature 2
Source: 2A and 2D
Description: differences in species at Gestational week 27
Abundance in Group 1: decreased abundance in Women at 27 weeks Pregnant
| NCBI | Quality Control | Links |
|---|---|---|
| Streptococcus thermophilus | ||
| Lactobacillus acidophilus |
Revision editor(s): Miss Lulu
