Altered oral microbiota in chronic hepatitis B patients with different tongue coatings/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by Claregrieve1 on 2022/07/11

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): Claregrieve1, WikiWorks

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Tongue Glossus,Tongue,tongue
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Chronic hepatitis B virus infection chronic Hepatitis B,chronic hepatitis B infection,chronic hepatitis B virus infection,hepatitis B infection, chronic,hepatitis B, chronic,Chronic hepatitis B virus infection
Group 0 name Corresponds to the control (unexposed) group for case-control studies
healthy controls
Group 1 name Corresponds to the case (exposed) group for case-control studies
chronic hepatitis B yellow tongue coating patients
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
patients diagnosed with chronic hepatitis B per "The Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2010 version)" with a yellow tongue coating
Group 0 sample size Number of subjects in the control (unexposed) group
22
Group 1 sample size Number of subjects in the case (exposed) group
28
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
3 months

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Ion Torrent

Statistical Analysis

Statistical test
Metastats
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
Matched on Factors on which subjects have been matched on in a case-control study
age, sex

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Chao1 Abundance-based estimator of species richness
unchanged

Signature 1

Reviewed Marked as Reviewed by Claregrieve1 on 2022/07/11

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): Claregrieve1, WikiWorks

Source: Figure 2B, Figure 3A

Description: Differentially abundant taxa between chronic hepatitis B yellow tongue coating patients and healthy controls

Abundance in Group 1: increased abundance in chronic hepatitis B yellow tongue coating patients

NCBI Quality ControlLinks
Burkholderiaceae
Cardiobacteriaceae
Comamonadaceae
Comamonas
Lautropia
Neisseria
Neisseriaceae
Pseudomonadota

Revision editor(s): Claregrieve1, WikiWorks

Signature 2

Reviewed Marked as Reviewed by Claregrieve1 on 2022/07/11

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): Claregrieve1, WikiWorks

Source: Figure 2B, Figure 3A

Description: Differentially abundant taxa between chronic hepatitis B yellow tongue coating patients and healthy controls

Abundance in Group 1: decreased abundance in chronic hepatitis B yellow tongue coating patients

NCBI Quality ControlLinks
Bifidobacteriaceae
Campylobacter
Campylobacteraceae
Candidatus Saccharimonas
Parvimonas
Peptoclostridium
Scardovia

Revision editor(s): Claregrieve1, WikiWorks