Altered oral microbiota in chronic hepatitis B patients with different tongue coatings/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by Claregrieve1 on 2022/07/11
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Tongue Glossus,Tongue,tongue
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Chronic hepatitis B virus infection chronic Hepatitis B,chronic hepatitis B infection,chronic hepatitis B virus infection,hepatitis B infection, chronic,hepatitis B, chronic,Chronic hepatitis B virus infection
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- chronic hepatitis B white tongue coating patients
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- patients diagnosed with chronic hepatitis B per "The Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2010 version)" with a white tongue coating
- Group 0 sample size Number of subjects in the control (unexposed) group
- 22
- Group 1 sample size Number of subjects in the case (exposed) group
- 25
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Ion Torrent
Statistical Analysis
- Statistical test
- Metastats
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- Matched on Factors on which subjects have been matched on in a case-control study
- age, sex
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Claregrieve1 on 2022/07/11
Source: Figure 2B, Figure 3A
Description: Differentially abundant taxa between healthy controls and chronic hepatitis B white tongue coating patients
Abundance in Group 1: increased abundance in chronic hepatitis B white tongue coating patients
| NCBI | Quality Control | Links |
|---|---|---|
| Bergeyella | ||
| Bulleidia | ||
| Centipeda | ||
| Porphyromonadaceae | ||
| Porphyromonas |
Revision editor(s): Claregrieve1, WikiWorks
Signature 2
Reviewed Marked as Reviewed by Claregrieve1 on 2022/07/11
Source: Figure 2B, Figure 3A
Description: Differentially abundant taxa between healthy controls and chronic hepatitis B white tongue coating patients
Abundance in Group 1: decreased abundance in chronic hepatitis B white tongue coating patients
| NCBI | Quality Control | Links |
|---|---|---|
| Actinomyces | ||
| Actinomycetaceae | ||
| Alysiella | ||
| Cardiobacteriaceae | ||
| Mycoplasmataceae | ||
| Pseudoramibacter | ||
| Scardovia |
Revision editor(s): Claregrieve1, WikiWorks
