Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation/Experiment 1
From BugSigDB
Subjects
- Location of subjects
- Malaysia
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Caecum Blind intestine,Blindgut,Caeca,Caecum,Ceca,Cecum,Intestinum caecum,Intestinum crassum caecum,Intestinum crassum cecum,caecum
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Leukemia blood (leukemia),leukemia,leukemia (disease),leukemia, disease,leukemia, malignant,leukemias,leukemias, general,Leukemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- survivors of acute lymphoblastic leukemia
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- adult surviors of childhood leukemia
- Group 0 sample size Number of subjects in the control (unexposed) group
- 61
- Group 1 sample size Number of subjects in the case (exposed) group
- 73
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 4
Alpha Diversity
- Chao1 Abundance-based estimator of species richness
- decreased
Signature 1
Needs review
Source: Figure 2,Supplementary table S1
Description: Alterations to microbial communities in adult survivors of acute lymphoblastic leukemia
Abundance in Group 1: increased abundance in survivors of acute lymphoblastic leukemia
| NCBI | Quality Control | Links |
|---|---|---|
| Actinomycetota | ||
| Corynebacterium | ||
| Corynebacteriaceae | ||
| Peptoniphilus | ||
| Finegoldia | ||
| Archaea | ||
| Staphylococcaceae | ||
| Staphylococcus | ||
| Actinomyces |
Revision editor(s): WikiWorks
Signature 2
Needs review
Source: Figure 2,Supplementary table S1
Description: Alterations to microbial communities in adult survivors of acute lymphoblastic leukemia
Abundance in Group 1: decreased abundance in survivors of acute lymphoblastic leukemia
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroidales | ||
| Bacteroidia | ||
| Bacteroidota | ||
| Oscillospiraceae | ||
| Faecalibacterium | ||
| Ruminococcus | ||
| Rikenellaceae | ||
| Lachnospira | ||
| Desulfovibrionales | ||
| Deltaproteobacteria | ||
| Desulfovibrionaceae |
Revision editor(s): WikiWorks
