Daidzein Intake Is Associated with Equol Producing Status through an Increase in the Intestinal Bacteria Responsible for Equol Production/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by Atrayees on 2023-6-28

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, Victoria

Subjects

Location of subjects
Japan
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Equol (3S)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-7-ol,Equol,equol
Group 0 name Corresponds to the control (unexposed) group for case-control studies
equol non-producers
Group 1 name Corresponds to the case (exposed) group for case-control studies
equol producers
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
The equol production status was defined by a urinary log 10 - transformed equol/daidzein ratio of −1.75 or more as described previously
Group 0 sample size Number of subjects in the control (unexposed) group
586
Group 1 sample size Number of subjects in the case (exposed) group
458

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Mann-Whitney (Wilcoxon)
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
increased
Chao1 Abundance-based estimator of species richness
increased

Signature 1

Reviewed Marked as Reviewed by Atrayees on 2023-6-28

Curated date: 2021/01/10

Curator: Shaimaa Elsafoury

Revision editor(s): WikiWorks

Source: Table 2

Description: Relative abundance of species (percentage of the total bacterial 16sRNA).

Abundance in Group 1: increased abundance in equol producers

NCBI Quality ControlLinks
Adlercreutzia equolifaciens subsp. celatus
Slackia isoflavoniconvertens

Revision editor(s): WikiWorks