Lower airway microbiota and mycobiota in children with severe asthma

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology: Right lung middle lobe bronchiole Bronchiole of middle right lobe,Bronchiole of right middle lobe,Bronchiole of right middle lobe of lung,Right lung middle lobe bronchiole,right lung middle lobe bronchiole

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology: Asthma Airway hyperreactivity,asthma,Asthma (disorder),Asthma NOS,Asthma NOS (disorder),ASTHMA NOS W (AC) EXAC,Asthma unspecified,Asthma unspecified (disorder),Asthma, Bronchial,Asthma, unspecified,Asthma, unspecified type, with acute exacerbation,Asthma, unspecified type, without mention of status asthmaticus,Asthmas,Asthmatic,BHR - Bronchial hyperreactivity,Bronchial asthma,Bronchial Hyperreactivities,Bronchial hyperreactivity,bronchial hyperreactivity,Bronchial hyperresponsiveness,Bronchial hypersensitivity,chronic obstructive asthma,chronic obstructive asthma with acute exacerbation,chronic obstructive asthma with status asthmaticus,DUST PNEUMONOPATHY NEC,Exercise induced asthma,exercise induced asthma,Exercise-induced asthma,exercise-induced asthma,Exercise-induced asthma (disorder),Hyperreactive airway disease,Hyperreactive airways disease,Hyperreactivities, Bronchial,Hyperreactivity, Bronchial,Other forms of asthma,Pneumonopathy due to inhalation of other dust,Pneumopathy due to inhalation of other dust,Pneumopathy due to inhalation of other dust (disorder),Pneumopathy due to inhalation of other dust NOS,Pneumopathy due to inhalation of other dust NOS (disorder),Asthma

Group 0 name Corresponds to the control (unexposed) group for case-control studies: non-asthma

Group 1 name Corresponds to the case (exposed) group for case-control studies: severe asthma

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group: severe asthma

16S variable region One or more hypervariable region(s) of the bacterial 16S gene: V4

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance: Illumina

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).: relative abundances

Significance threshold p-value or FDR threshold used for differential abundance testing (if any): 0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?: No

Shannon Estimator of species richness and species evenness: more weight on species richness: unchanged

Reviewed Marked as Reviewed by Claregrieve1 on 2022/10/23

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): Fatima, Claregrieve1, WikiWorks

Source: Figure 1a, 1b

Description: Differentially abundant genera between severe asthma and non-asthma patients

Abundance in Group 1: increased abundance in severe asthma