Dysbiosis patterns during re-induction/salvage versus induction chemotherapy for acute leukemia/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by Claregrieve1 on 2023-5-7

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks

Subjects

Location of subjects
United States of America
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Leukemia blood (leukemia),leukemia,leukemia (disease),leukemia, disease,leukemia, malignant,leukemias,leukemias, general,Leukemia
Group 0 name Corresponds to the control (unexposed) group for case-control studies
repeat therapy
Group 1 name Corresponds to the case (exposed) group for case-control studies
induction
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
acute leukemia patients undergoing chemotherapy
Group 0 sample size Number of subjects in the control (unexposed) group
7
Group 1 sample size Number of subjects in the case (exposed) group
13

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.01
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
4

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged

Signature 1

Reviewed Marked as Reviewed by Claregrieve1 on 2023-5-7

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): WikiWorks, Claregrieve1

Source: Figure 2b

Description: Composition of microbial communities during induction and repeat therapy in leukemia patients

Abundance in Group 1: increased abundance in induction

NCBI Quality ControlLinks
Bacteroides
Faecalibacterium
Oscillibacter
Parabacteroides
Ruminococcus

Revision editor(s): WikiWorks, Claregrieve1

Signature 2

Reviewed Marked as Reviewed by Claregrieve1 on 2023-5-7

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): WikiWorks, Claregrieve1

Source: Figure 2b

Description: Composition of microbial communities during induction and repeat therapy in leukemia patients

Abundance in Group 1: decreased abundance in induction

NCBI Quality ControlLinks
Actinomyces
Eggerthella
Enterococcus
Faecalicoccus
Lactobacillus
Subdoligranulum
Veillonella

Revision editor(s): WikiWorks, Claregrieve1