Microarray analysis reveals marked intestinal microbiota aberrancy in infants having eczema compared to healthy children in at-risk for atopic disease/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2024-2-26
Subjects
- Location of subjects
- Finland
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Eczema Eczema,eczema
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy control
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- child with eczema
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- child with eczema
- Group 0 sample size Number of subjects in the control (unexposed) group
- 19
- Group 1 sample size Number of subjects in the case (exposed) group
- 15
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Human Intestinal Tract Chip
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- ANOVA
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
- increased
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2024-2-25
Source: Table 2
Description: Differences in microbiota of healthy and eczematous children at 18 months of age
Abundance in Group 1: increased abundance in child with eczema
| NCBI | Quality Control | Links |
|---|---|---|
| Ruminococcus bromii | ||
| [Clostridium] nexile | ||
| [Ruminococcus] lactaris | ||
| [Clostridium] leptum | ||
| [Clostridium] cellulosi |
Signature 2
Reviewed Marked as Reviewed by Folakunmi on 2024-2-25
Source: Table 2
Description: Differences in microbiota of healthy and eczematous children at 18 months of age
Abundance in Group 1: decreased abundance in child with eczema
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides fragilis | ||
| Bacteroides ovatus | ||
| Phocaeicola plebeius | ||
| Bacteroides stercoris | ||
| Bacteroides uniformis | ||
| Phocaeicola vulgatus | ||
| Alloprevotella tannerae | ||
| Bacteroidota |
Revision editor(s): WikiWorks
