Alterations of gastric mucosal microbiota across different stomach microhabitats in a cohort of 276 patients with gastric cancer

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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27
study design
cross-sectional observational, not case-control
Citation
PMID PubMed identifier for scientific articles.
30584008
DOI Digital object identifier for electronic documents.
10.1016/j.ebiom.2018.12.034
URI
Authors
Liu X, Shao L, Liu X, Ji F, Mei Y, Cheng Y, Liu F, Yan C, Li L, Ling Z
Journal
EBioMedicine
Year
2019
Keywords:
Gastric cancer, Gastric microbiota, Helicobacter pylori, Stomach microhabitat, Tumor microenvironment
BACKGROUND: As part of the tumor microenvironment, the gastric microbiota play vital roles in tumor initiation, progression and metastasis, but stomach microhabitats are not always uniform. We aimed to characterize differences of gastric microbiota in stomach microhabitats associated with gastric cancer (GC) development. METHODS: A cohort of 276 GC patients without preoperative chemotherapy was enrolled retrospectively, and 230 normal, 247 peritumoral and 229 tumoral tissues were obtained for gastric microbiota analysis targeting the 16S rRNA gene by MiSeq sequencing. The microbial diversity and composition, bacterial co-occurrence correlations and predictive functional profiles were compared across different microhabitats. FINDINGS: GC-specific stomach microhabitats, not GC stages or types, determine the composition and diversity of the gastric microbiota. Most notably, bacterial richness was decreased in peritumoral and tumoral microhabitats, and the correlation network of abundant gastric bacteria was simplified in tumoral microhabitat. Helicobacter pylori (HP), Prevotella copri and Bacteroides uniformis were significantly decreased, whereas Prevotella melaninogenica, Streptococcus anginosus and Propionibacterium acnes were increased in tumoral microhabitat. Higher HP colonisation influenced the overall structure of the gastric microbiota in normal and peritumoral microhabitats. PiCRUSt analysis revealed that genes associated with nucleotide transport and metabolism and amino acid transport and metabolism were significantly enriched in tumoral microbiota, while gastric acid secretion was significantly higher in HP positive group of the tumoral microbiota. INTERPRETATION: Our present study provided new insights into the roles of gastric microbiota in different stomach microhabitats in gastric carcinogenesis, especially the pathogenesis of HP. FUND: National Natural Science Foundation of China.

Experiment 1


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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, ChiomaBlessing

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Stomach Anterior intestine,Gaster,Mesenteron,Stomach chamber,Ventriculus,Stomach,stomach
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Gastric cancer Ca body - stomach,ca greater curvature of stomach,Ca lesser curvature - stomach,cancer of stomach,gastric cancer,gastric cancer, intestinal,gastric neoplasm,malignant gastric neoplasm,malignant gastric tumor,malignant neoplasm of body of stomach,malignant neoplasm of lesser curve of stomach,malignant neoplasm of stomach,malignant neoplasm of the stomach,malignant stomach neoplasm,malignant tumor of body of stomach,malignant tumor of greater curve of stomach,malignant tumor of lesser curve of stomach,malignant tumor of stomach,malignant tumor of the stomach,stomach cancer,Gastric cancer
Group 0 name Corresponds to the control (unexposed) group for case-control studies
normal tissues
Group 1 name Corresponds to the case (exposed) group for case-control studies
peritumoral tissues
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
gastric cancer
Group 0 sample size Number of subjects in the control (unexposed) group
230
Group 1 sample size Number of subjects in the case (exposed) group
247
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
1 month

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Mann-Whitney (Wilcoxon)
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes
Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
age, sex

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Chao1 Abundance-based estimator of species richness
decreased
Simpson Estimator of species richness and species evenness: more weight on species evenness
decreased
Richness Number of species
decreased

Signature 1

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Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks, ChiomaBlessing

Source: Figure 2a, 2c, 2f

Description: Differentially abundant taxa between peritumoral tissues and normal tissues

Abundance in Group 1: increased abundance in peritumoral tissues

NCBI Quality ControlLinks
Akkermansia muciniphila   
Aquabacter   
Bacteroides fragilis   
Halomonadaceae   
Halomonas   
Helicobacter   
Helicobacteraceae   
Lactobacillaceae   
Lactobacillus   
Methylobacterium   
Peptostreptococcaceae   
Peptostreptococcus   
Pseudomonadota   
Selenomonas   
Shewanella   
Shewanellaceae   
Streptococcaceae   
Streptococcus   
Veillonella   
Veillonellaceae   

Revision editor(s): WikiWorks, ChiomaBlessing

Signature 2

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Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks, ChiomaBlessing

Source: Figure 2a, 2c, 2f

Description: Differentially abundant taxa between peritumoral tissues and normal tissues

Abundance in Group 1: decreased abundance in peritumoral tissues

NCBI Quality ControlLinks
Acidobacteriota   
Bacillaceae   
Bacillota   
Bacillus   
Bacillus cereus   
Bacteroidaceae   
Bacteroides   
Bacteroidota   
Chloroflexota   
Corynebacterium   
Enterobacteriaceae   
Faecalibacterium   
Fusobacteriota   
Fusobacterium   
Oscillospiraceae   
Phascolarctobacterium   
Porphyromonadaceae   
Prevotella   
Prevotellaceae   
Propionibacterium   
Pseudomonas   
Segatella copri   
Sphingomonadaceae   
Sphingomonas   

Revision editor(s): WikiWorks, ChiomaBlessing

Experiment 2


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Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, ChiomaBlessing

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
peritumoral tissues
Group 1 name Corresponds to the case (exposed) group for case-control studies
tumoral tissues
Group 0 sample size Number of subjects in the control (unexposed) group
247
Group 1 sample size Number of subjects in the case (exposed) group
229

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
increased
Chao1 Abundance-based estimator of species richness
decreased
Simpson Estimator of species richness and species evenness: more weight on species evenness
increased
Richness Number of species
unchanged

Signature 1

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Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks, ChiomaBlessing

Source: Figure 2a, 2c, 2f

Description: Differentially abundant taxa between tumoral tissues and peritumoral tissues

Abundance in Group 1: increased abundance in tumoral tissues

NCBI Quality ControlLinks
Acidobacteriota   
Azotobacter group   
Bacillus   
Bacillus cereus   
Chloroflexota   
Enterobacteriaceae   
Lachnospiraceae   
Prevotella   
Prevotella melaninogenica   
Prevotellaceae   
Propionibacterium   
Pseudomonas   
Streptococcus anginosus   

Revision editor(s): WikiWorks, ChiomaBlessing

Signature 2

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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks, ChiomaBlessing

Source: Figure 2a, 2c, 2f

Description: Differentially abundant taxa between tumoral tissues and peritumoral tissues

Abundance in Group 1: decreased abundance in tumoral tissues

NCBI Quality ControlLinks
Faecalibacterium   
Halomonadaceae   
Halomonas   
Helicobacter pylori   
Oscillospiraceae   
Phascolarctobacterium   
Porphyromonadaceae   
Pseudomonadota   
Shewanella   
Shewanellaceae   
Sphingobacteriaceae   
Sphingomonas   

Revision editor(s): WikiWorks, ChiomaBlessing

Experiment 3


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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, ChiomaBlessing

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
normal tissues
Group 0 sample size Number of subjects in the control (unexposed) group
230

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Chao1 Abundance-based estimator of species richness
decreased
Simpson Estimator of species richness and species evenness: more weight on species evenness
decreased
Richness Number of species
decreased

Signature 1

EditHistoryDelete
Flag for review
Your review change was submitted
Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks, ChiomaBlessing

Source: Figure 2a, 2c, 2f

Description: Differentially abundant taxa between tumoral tissues and normal tissues

Abundance in Group 1: increased abundance in tumoral tissues

NCBI Quality ControlLinks
Actinomycetota   
Akkermansia muciniphila   
Bacillota   
Bacillus   
Corynebacterium   
Cutibacterium acnes   
Fusobacteriota   
Fusobacterium   
Halomonas   
Lachnospiraceae   
Lactobacillus   
Peptostreptococcaceae   
Prevotella melaninogenica   
Propionibacterium   
Selenomonas   
Shewanella   
Shewanellaceae   
Streptococcus   
Streptococcus anginosus   
Veillonellaceae   

Revision editor(s): WikiWorks, ChiomaBlessing

Signature 2

EditHistoryDelete
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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks, ChiomaBlessing

Source: Figure 2a, 2c, 2f

Description: Differentially abundant taxa between tumoral tissues and normal tissues

Abundance in Group 1: decreased abundance in tumoral tissues

NCBI Quality ControlLinks
Azotobacter group   
Bacteroidaceae   
Bacteroides   
Bacteroides uniformis   
Helicobacter   
Helicobacter pylori   
Helicobacteraceae   
Pseudomonadota   
Pseudomonas   
Segatella copri   
Sphingomonas   

Revision editor(s): WikiWorks, ChiomaBlessing

Experiment 4


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Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, ChiomaBlessing

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
early stage normal
Group 1 name Corresponds to the case (exposed) group for case-control studies
early stage tumor
Group 0 sample size Number of subjects in the control (unexposed) group
112
Group 1 sample size Number of subjects in the case (exposed) group
116

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Chao1 Abundance-based estimator of species richness
decreased
Simpson Estimator of species richness and species evenness: more weight on species evenness
unchanged

Signature 1

EditHistoryDelete
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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): Claregrieve1, WikiWorks

Source: Figure 4k, 4l, 4m, 4n

Description: Early-stage gastric microbiota between normal and tumor samples

Abundance in Group 1: increased abundance in early stage tumor

NCBI Quality ControlLinks
Cutibacterium acnes   
Streptococcus anginosus   

Revision editor(s): Claregrieve1, WikiWorks

Signature 2

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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): Claregrieve1, WikiWorks

Source: Figure 4k, 4l, 4m, 4n

Description: Early-stage gastric microbiota between normal and tumor samples

Abundance in Group 1: decreased abundance in early stage tumor

NCBI Quality ControlLinks
Segatella copri   
Sphingomonas yabuuchiae   

Revision editor(s): Claregrieve1, WikiWorks

Experiment 5


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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, ChiomaBlessing

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
early stage peritumor
Group 1 sample size Number of subjects in the case (exposed) group
118

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Chao1 Abundance-based estimator of species richness
decreased
Simpson Estimator of species richness and species evenness: more weight on species evenness
unchanged

Signature 1

EditHistoryDelete
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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): Claregrieve1, WikiWorks

Source: Figure 4k, 4l, 4m, 4n

Description: Early-stage gastric microbiota in normal and peritumor samples

Abundance in Group 1: decreased abundance in early stage peritumor

NCBI Quality ControlLinks
Sphingomonas yabuuchiae   

Revision editor(s): Claregrieve1, WikiWorks

Experiment 6


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Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, ChiomaBlessing

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
late stage normal
Group 1 name Corresponds to the case (exposed) group for case-control studies
late stage tumor
Group 0 sample size Number of subjects in the control (unexposed) group
118
Group 1 sample size Number of subjects in the case (exposed) group
113

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Chao1 Abundance-based estimator of species richness
decreased
Simpson Estimator of species richness and species evenness: more weight on species evenness
unchanged

Signature 1

EditHistoryDelete
Flag for review
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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): Claregrieve1, WikiWorks

Source: Figure 4k, 4l, 4m, 4n

Description: Late-stage gastric microbiota in normal and tumor samples

Abundance in Group 1: increased abundance in late stage tumor

NCBI Quality ControlLinks
Cutibacterium acnes   
Streptococcus anginosus   

Revision editor(s): Claregrieve1, WikiWorks

Experiment 8


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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, ChiomaBlessing

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
late stage peritumor
Group 1 sample size Number of subjects in the case (exposed) group
129

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Chao1 Abundance-based estimator of species richness
decreased
Simpson Estimator of species richness and species evenness: more weight on species evenness
decreased

Signature 1

EditHistoryDelete
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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): Claregrieve1, WikiWorks

Source: Figure 4k, 4l, 4m, 4n

Description: late-stage gastric microbiota in normal vs peritumor samples

Abundance in Group 1: decreased abundance in late stage peritumor

NCBI Quality ControlLinks
Segatella copri   

Revision editor(s): Claregrieve1, WikiWorks

Experiment 9


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Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): Claregrieve1, WikiWorks, ChiomaBlessing

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
normal HP-
Group 1 name Corresponds to the case (exposed) group for case-control studies
normal HP+
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
normal samples that are H. Pylori positive
Group 0 sample size Number of subjects in the control (unexposed) group
64
Group 1 sample size Number of subjects in the case (exposed) group
166

Lab analysis

Statistical Analysis

Statistical test
LEfSe
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
2

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Chao1 Abundance-based estimator of species richness
decreased
Simpson Estimator of species richness and species evenness: more weight on species evenness
decreased

Signature 1

EditHistoryDelete
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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks

Source: Figure 5l, Supp FigS9

Description: Taxonomic difference of gastric mucosal microbiota between histopathological H. pylori (HP+ and HP-) groups of gastric cancer in normal microhabitat

Abundance in Group 1: increased abundance in normal HP+

NCBI Quality ControlLinks
Burkholderiales   
Massilia   
Oxalobacteraceae   
Bifidobacteriaceae   
Bifidobacterium   
Bifidobacteriales   
Corynebacterium   
Corynebacteriaceae   
Actinomycetaceae   
Actinomyces   
Methylobacterium   
Methylobacteriaceae   
Lachnospiraceae   
Sphingomonadales   
Sphingomonas   
Sphingomonadaceae   
Alphaproteobacteria   
Streptococcaceae   
Streptococcus   
Helicobacteraceae   
Helicobacter   
Campylobacterales   
Campylobacterota   
Pseudomonadota   

Revision editor(s): WikiWorks

Signature 2

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Curator: Rimsha Azhar

Revision editor(s): Claregrieve1, WikiWorks

Source: Figure 5, Supp FigS9

Description: Taxonomic difference of gastric mucosal microbiota between histopathological H. pylori (HP+ and HP-) groups of gastric cancer in normal microhabitat

Abundance in Group 1: decreased abundance in normal HP+

NCBI Quality ControlLinks
Acidaminococcaceae   
Alteromonadales   
Betaproteobacteria   
Blautia   
Clostridia   
Dialister   
Eubacteriales   
Faecalibacterium   
Bacillota   
Gemmiger   
Halomonadaceae   
Halomonas   
Oceanospirillales   
Oscillospiraceae   
Phascolarctobacterium   
Prevotella   
Prevotellaceae   
Roseburia   
Ruminococcus   
Shewanella   
Shewanellaceae   
Lachnospiraceae incertae sedis   

Revision editor(s): Claregrieve1, WikiWorks

Experiment 10


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Curator: WikiWorks

Revision editor(s): Claregrieve1, WikiWorks, ChiomaBlessing

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
peritumor HP-
Group 1 name Corresponds to the case (exposed) group for case-control studies
peritumor HP+
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
peritumor samples that are H. Pylori positive
Group 0 sample size Number of subjects in the control (unexposed) group
65
Group 1 sample size Number of subjects in the case (exposed) group
182

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Chao1 Abundance-based estimator of species richness
unchanged
Simpson Estimator of species richness and species evenness: more weight on species evenness
decreased

Signature 1

EditHistoryDelete
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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): Claregrieve1, WikiWorks

Source: Figure S10

Description: Taxonomic difference of gastric mucosal microbiota between histopathological H. pylori (HP+ and HP-) groups of gastric cancer in peritumor microhabitat

Abundance in Group 1: increased abundance in peritumor HP+

NCBI Quality ControlLinks
Bacillaceae   
Bacillales   
Bacillus   
Campylobacterales   
Campylobacterota   
Gemella   
Helicobacter   
Helicobacteraceae   
Pseudomonadota   
Streptococcaceae   
Streptococcus   
Bacillales Family X. Incertae Sedis   

Revision editor(s): Claregrieve1, WikiWorks

Signature 2

EditHistoryDelete
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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks

Source: Figure S10

Description: Taxonomic difference of gastric mucosal microbiota between histopathological H. pylori (HP+ and HP-) groups of gastric cancer in peritumor microhabitat

Abundance in Group 1: decreased abundance in peritumor HP+

NCBI Quality ControlLinks
Clostridia   
Phascolarctobacterium   
Acidaminococcaceae   
Eubacteriales   
Roseburia   
Faecalibacterium   
Alistipes   
Rikenellaceae   
Dialister   
Oscillospiraceae   
Gemmiger   
Megamonas   
Bacillus   
Lactobacillales   
Parabacteroides   

Revision editor(s): WikiWorks

Experiment 11


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Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): Claregrieve1, WikiWorks, ChiomaBlessing

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
tumor HP-
Group 1 name Corresponds to the case (exposed) group for case-control studies
tumor HP+
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
tumor samples that are H. Pylori positive
Group 0 sample size Number of subjects in the control (unexposed) group
77
Group 1 sample size Number of subjects in the case (exposed) group
152

Lab analysis

Statistical Analysis

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Chao1 Abundance-based estimator of species richness
unchanged
Simpson Estimator of species richness and species evenness: more weight on species evenness
unchanged

Signature 1

EditHistoryDelete
Flag for review
Your review change was submitted
Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks

Source: Figure S11

Description: Taxonomic difference of gastric mucosal microbiota between histopathological H. pylori (HP+ and HP-) groups of gastric cancer in tumor microhabitat

Abundance in Group 1: increased abundance in tumor HP+

NCBI Quality ControlLinks
Staphylococcaceae   
Staphylococcus   
Bacteroidaceae   
Bacteroides   
Caulobacterales   
Caulobacteraceae   
Brevundimonas   
Hyphomicrobiales   
Alphaproteobacteria   
Blautia   
Burkholderiales   
Massilia   
Sphingomonadales   
Sphingobacteriaceae   
Novosphingobium   
Helicobacteraceae   
Helicobacter   
Campylobacterales   
Campylobacterota   

Revision editor(s): WikiWorks

Signature 2

EditHistoryDelete
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Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/27

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks

Source: Figure S11

Description: Taxonomic difference of gastric mucosal microbiota between histopathological H. pylori (HP+ and HP-) groups of gastric cancer in tumor microhabitat

Abundance in Group 1: decreased abundance in tumor HP+

NCBI Quality ControlLinks
Acinetobacter   
Moraxellaceae   
Ruminococcus   
Pseudomonas   
Azotobacter group   
Pseudomonadales   
Betaproteobacteria   
Brucellaceae   
Sphingomonas   
Bifidobacteriales   
Bifidobacterium   
Bifidobacteriaceae   
Pseudomonadota   

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