Intestinal Microbiota at Engraftment Influence Acute Graft-Versus-Host Disease via the Treg/Th17 Balance in Allo-HSCT Recipients/Experiment 1
From BugSigDB
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Graft versus host disease disease, graft-versus-host,disease, graft-VS-host,disease, homologous wasting,disease, runt,diseases, graft-versus-host,diseases, graft-VS-host,graft versus host disease,graft VS host disease,graft VS. host disease,graft-versus-host disease,graft-versus-host disease, resistance to,graft-versus-host disease, susceptibility to,graft-versus-host diseases,graft-versus-host-disease,graft-VS-host disease,graft-VS-host diseases,GVH,GVHD,GVHDS,homologous wasting disease,runt disease,Graft versus host disease
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Grades 0-I (non-acute graft-host disease)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Grades II-IV (acute graft-host-disease)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- patients diagnoised with acute graft-versus-host disease (aGVHD)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 49
- Group 1 sample size Number of subjects in the case (exposed) group
- 32
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
- Inverse Simpson Modification of Simpsons index D as 1/D to obtain high values in datasets of high diversity and vice versa
- decreased
- Richness Number of species
- decreased
Signature 1
Reviewed Marked as Reviewed by Atrayees on 2023-7-11
Source: Figure 3a, b and text
Description: Differences of intestinal microbiota at engraftment between acute graft-verse-house disease (aGVHD) and non-acute graft-versus host disease (non-aGVHD) patients
Abundance in Group 1: increased abundance in Grades II-IV (acute graft-host-disease)
| NCBI | Quality Control | Links |
|---|---|---|
| Porphyromonadaceae | ||
| Enterobacteriaceae | ||
| Enterobacterales | ||
| Gammaproteobacteria | ||
| Pseudomonadota |
Revision editor(s): WikiWorks
Signature 2
Reviewed Marked as Reviewed by Atrayees on 2023-7-11
Source: Figure 3a, b and text
Description: Differences of intestinal microbiota at engraftment between acute graft-verse-house disease (aGVHD) and non-acute graft-versus host disease (non-aGVHD) patients
Abundance in Group 1: decreased abundance in Grades II-IV (acute graft-host-disease)
| NCBI | Quality Control | Links |
|---|---|---|
| Eubacteriaceae | ||
| Lachnospiraceae | ||
| Peptostreptococcaceae | ||
| Oscillospiraceae | ||
| Eubacteriales | ||
| Clostridia | ||
| Erysipelotrichaceae | ||
| Lachnoclostridium | ||
| Blautia |
Revision editor(s): WikiWorks
