Intestinal microbiota development in preterm neonates and effect of perinatal antibiotics
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Quality control
- Retracted paper
- Contamination issues suspected
- Batch effect issues suspected
- Uncontrolled confounding suspected
- Results are suspect (various reasons)
- Tags applied
Experiment 1
Subjects
- Location of subjects
- Spain
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Premature birth Birth, Premature,Birth, Preterm,Births, Premature,Births, Preterm,Premature Births,Preterm Birth,Preterm Births,Premature birth,premature birth
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 2-day old Full-term infants(born after uncomplicated pregnancy)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 2-day old Pre-term infants
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- infants born at gestational ages between 24 and 32 weeks
- Group 0 sample size Number of subjects in the control (unexposed) group
- 13
- Group 1 sample size Number of subjects in the case (exposed) group
- 27
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Ion Torrent
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- ANOVA
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Signature 1
Source: Results within text under the subheading "Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants" Line 7 to 15
Description: Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants
Abundance in Group 1: increased abundance in 2-day old Pre-term infants
NCBI | Quality Control | Links |
---|---|---|
Bifidobacteriaceae | ||
Comamonadaceae | ||
Propionibacteriaceae | ||
Streptococcaceae | ||
unclassified Actinomycetota | ||
unclassified Bacilli | ||
unclassified Lactobacillales |
Revision editor(s): WikiWorks, ChiomaBlessing
Signature 2
Source: Results within text under the subheading "Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants" (Line 7 to 15)
Description: Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants
Abundance in Group 1: decreased abundance in 2-day old Pre-term infants
NCBI | Quality Control | Links |
---|---|---|
Bacteroidaceae | ||
Clostridiaceae | ||
Micrococcaceae | ||
Pasteurellaceae | ||
Porphyromonadaceae |
Revision editor(s): WikiWorks, ChiomaBlessing
Experiment 2
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 10-day old Full-term infants(born after uncomplicated pregnancy)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 10-day old Pre-term
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- born at gestational ages between 24 and 32 weeks
Lab analysis
Statistical Analysis
Signature 1
Source: Results within text under the subheading "Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants" (line 15 to 22)
Description: Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants
Abundance in Group 1: increased abundance in 10-day old Pre-term
NCBI | Quality Control | Links |
---|---|---|
Enterobacteriaceae | ||
Gammaproteobacteria | ||
Micrococcaceae |
Revision editor(s): WikiWorks, ChiomaBlessing
Signature 2
Curated date: 2021/01/10
Curator: Mst Afroza Parvin
Revision editor(s): WikiWorks, Atrayees, ChiomaBlessing
Source: Results within text under the subheading "Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants" (line 15 to 22)
Description: Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants
Abundance in Group 1: decreased abundance in 10-day old Pre-term
NCBI | Quality Control | Links |
---|---|---|
Veillonellaceae | ||
Bacteroidaceae | ||
Bifidobacteriaceae | ||
Clostridiaceae | ||
Coriobacteriaceae | ||
Lactobacillaceae | ||
Pasteurellaceae | ||
Porphyromonadaceae | ||
unclassified Actinomycetota |
Revision editor(s): WikiWorks, Atrayees, ChiomaBlessing
Experiment 3
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 30 and 90-day old Full-term infants
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 30 and 90-day old Pre-term infants
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- infants born at gestational ages between 24 and 32 weeks
Lab analysis
Statistical Analysis
Signature 1
Source: Results within text under the subheading "Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants" (line 23 to 26)
Description: Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants
Abundance in Group 1: increased abundance in 30 and 90-day old Pre-term infants
NCBI | Quality Control | Links |
---|---|---|
Enterobacteriaceae |
Signature 2
Source: Results within text under the subheading "Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants" (line 23 to 26)
Description: Establishment of Intestinal Microbiota in VLBW Preterm Neonates Compared with FTVDBF Infants
Abundance in Group 1: decreased abundance in 30 and 90-day old Pre-term infants
NCBI | Quality Control | Links |
---|---|---|
Bacteroidaceae |
Experiment 4
Subjects
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Delivery method DeliveryMethod,Delivery method,delivery method
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 10-day old cesarean-delivered pre-term neontes
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 10-day old vaginally-delivered pre-term neonates
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- 10-day old pre-term infants who were delivered vaginally.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 20
- Group 1 sample size Number of subjects in the case (exposed) group
- 7
Lab analysis
- Sequencing type
- PCR
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
Statistical Analysis
Signature 1
Source: Results within text under the sub-heading "Impact of Delivery Mode and Antibiotics Use on the Establishment of Intestinal Microbiota" (Line 6-8)
Description: Impact of Delivery method on the Intestinal Microbiota between 10-day old vaginally-delivered pre-term neonates and cesarean-delivered pre-term neonates, as observed by qPCR.
Abundance in Group 1: increased abundance in 10-day old vaginally-delivered pre-term neonates
NCBI | Quality Control | Links |
---|---|---|
Bacteroides |
Revision editor(s): Folakunmi
Experiment 5
Subjects
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Antimicrobial agent antibiotic,antibiotics,Antibiotika,Antibiotikum,antibiotique,antimicrobial,antimicrobial agents,microbicide,microbicides,Antimicrobial agent,antimicrobial agent
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 2-day old full-term neonates not exposed to antibiotics (IAP/postnatal)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 2-day old pre-tem neonates exposed to antibiotics (IAP)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- antenatal/postnatal antibiotic exposure
- Group 0 sample size Number of subjects in the control (unexposed) group
- 14
- Group 1 sample size Number of subjects in the case (exposed) group
- 10
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
Statistical Analysis
Signature 1
Curated date: 2021/01/10
Curator: Mst Afroza Parvin
Revision editor(s): WikiWorks, Folakunmi, ChiomaBlessing
Source: Results within text under the subheading "Impact of Delivery Mode and Antibiotics Use on the Establishment of Intestinal Microbiota" (2nd paragraph, from line 11)
Description: Impact of Antibiotics Use on the Intestinal Microbiota between 2-day old full-term neonates not exposed to antibiotics (IAP/postnatal) and 2-day old pre-term neonates exposed to antibiotics (IAP)
Abundance in Group 1: decreased abundance in 2-day old pre-tem neonates exposed to antibiotics (IAP)
NCBI | Quality Control | Links |
---|---|---|
Lactobacillaceae |
Revision editor(s): WikiWorks, Folakunmi, ChiomaBlessing
Experiment 6
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 10-day old full-term neonates not exposed to antibiotics (IAP/postnatal)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 10-day old pre-tem neonates exposed to antibiotics (IAP)
Lab analysis
Statistical Analysis
Signature 1
Source: Results within text under the subheading "Impact of Delivery Mode and Antibiotics Use on the Establishment of Intestinal Microbiota" (2nd paragraph, from line 11)
Description: Impact of Antibiotics Use on the Intestinal Microbiota between 10-day old full-term neonates not exposed to antibiotics (IAP/postnatal) and 10-day old pre-tem neonates exposed to antibiotics (IAP)
Abundance in Group 1: decreased abundance in 10-day old pre-tem neonates exposed to antibiotics (IAP)
NCBI | Quality Control | Links |
---|---|---|
Micrococcaceae | ||
Propionibacteriaceae |
Revision editor(s): WikiWorks, ChiomaBlessing
Experiment 7
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 30-day old full-term neonates not exposed to antibiotics (IAP/postnatal)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 30-day old pre-tem neonates exposed to antibiotics (IAP)
Lab analysis
Statistical Analysis
Signature 1
Curated date: 2021/01/10
Curator: Mst Afroza Parvin
Revision editor(s): WikiWorks, Atrayees, ChiomaBlessing
Source: Results within text under the subheading "Impact of Delivery Mode and Antibiotics Use on the Establishment of Intestinal Microbiota" (2nd paragraph, from line 18)
Description: Impact of Antibiotics Use on the Intestinal Microbiota between 30-day old full-term neonates not exposed to antibiotics (IAP/postnatal) and 30-day old pre-term neonates exposed to antibiotics (IAP)
Abundance in Group 1: decreased abundance in 30-day old pre-tem neonates exposed to antibiotics (IAP)
NCBI | Quality Control | Links |
---|---|---|
Comamonadaceae | ||
Staphylococcaceae | ||
unclassified Bacilli |
Revision editor(s): WikiWorks, Atrayees, ChiomaBlessing
Experiment 8
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 90-day old full-term neonates not exposed to antibiotics (IAP/postnatal)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 90-day old pre-term neonates with mothers exposed to antibiotics (IAP)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- 90-day old pre-term neonates whose mothers received antibiotics (IAP) independently on whether or not the infant received antibiotics.
Lab analysis
Statistical Analysis
Signature 1
Source: Results within text under the subheading "Impact of Delivery Mode and Antibiotics Use on the Establishment of Intestinal Microbiota" (2nd paragraph, from line 31)
Description: Impact of Antibiotics Use on the Intestinal Microbiota between 90-day old full-term neonates not exposed to antibiotics (IAP/postnatal) and 90-day old pre-term neonates with mothers exposed to antibiotics (IAP)
Abundance in Group 1: decreased abundance in 90-day old pre-term neonates with mothers exposed to antibiotics (IAP)
NCBI | Quality Control | Links |
---|---|---|
Oscillospiraceae |
Revision editor(s): WikiWorks, ChiomaBlessing
Experiment 9
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 30-day old full-term neonates not exposed to antibiotics (IAP/postnatal)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 30-day old pre-tem neonates with mothers exposed to antibiotics (IAP)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- 30-day old pre-term neonates whose mothers received antibiotics (IAP) independently on whether or not the infant received antibiotics.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 5
- Group 1 sample size Number of subjects in the case (exposed) group
- 14
Lab analysis
Statistical Analysis
Signature 1
Source: Results within text under the subheading "Impact of Delivery Mode and Antibiotics Use on the Establishment of Intestinal Microbiota" (2nd paragraph, from line 24)
Description: Impact of Antibiotics Use on the Intestinal Microbiota between 30-day old full-term neonates not exposed to antibiotics (IAP/postnatal) and 30-day old pre-term neonates with mothers exposed to antibiotics (IAP)
Abundance in Group 1: increased abundance in 30-day old pre-tem neonates with mothers exposed to antibiotics (IAP)
NCBI | Quality Control | Links |
---|---|---|
Enterobacteriaceae |
Revision editor(s): WikiWorks, ChiomaBlessing
Signature 2
Source: Results within text under the subheading "Impact of Delivery Mode and Antibiotics Use on the Establishment of Intestinal Microbiota" (2nd paragraph, from line 20)
Description: Impact of Antibiotics Use on the Intestinal Microbiota between 30-day old full-term neonates not exposed to antibiotics (IAP/postnatal) and 30-day old pre-term neonates with mothers exposed to antibiotics (IAP)
Abundance in Group 1: decreased abundance in 30-day old pre-tem neonates with mothers exposed to antibiotics (IAP)
NCBI | Quality Control | Links |
---|---|---|
Bifidobacteriaceae | ||
Streptococcaceae | ||
unclassified Lactobacillales | ||
unclassified Actinomycetota |
Revision editor(s): WikiWorks, ChiomaBlessing
Experiment 10
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 30-day old pre-term neonates not exposed to antibiotics (IAP/postnatal)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 30-day old pre-tem neonates exposed to antibiotics (IAP/postnatal)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- pre-term infants and mothers exposed to antibiotics
- Group 1 sample size Number of subjects in the case (exposed) group
- 9
Lab analysis
- Sequencing type
- PCR
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
Statistical Analysis
Signature 1
Curated date: 2021/01/10
Curator: Mst Afroza Parvin
Revision editor(s): WikiWorks, Atrayees, ChiomaBlessing
Source: Results for qtPCR within text under the subheading "Impact of Delivery Mode and Antibiotics Use on the Establishment of Intestinal Microbiota", 5th paragraph)
Description: Impact of Antibiotics Use on the Intestinal Microbiota between 30-day old pre-term neonates not exposed to antibiotics (IAP/postnatal) and 30-day old pre-term neonates exposed to antibiotics (IAP/postnatal)
Abundance in Group 1: decreased abundance in 30-day old pre-tem neonates exposed to antibiotics (IAP/postnatal)
NCBI | Quality Control | Links |
---|---|---|
Staphylococcaceae |
Revision editor(s): WikiWorks, Atrayees, ChiomaBlessing
Signature 2
Source: Results for qtPCR within text under the subheading "Impact of Delivery Mode and Antibiotics Use on the Establishment of Intestinal Microbiota", 5th paragraph)
Description: Impact of Antibiotics Use on the Intestinal Microbiota between 30-day old pre-term neonates not exposed to antibiotics (IAP/postnatal) and 30-day old pre-term neonates exposed to antibiotics (IAP/postnatal)
Abundance in Group 1: increased abundance in 30-day old pre-tem neonates exposed to antibiotics (IAP/postnatal)
NCBI | Quality Control | Links |
---|---|---|
Enterobacteriaceae |
Revision editor(s): ChiomaBlessing
Experiment 11
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 90-day old pre-term neonates not exposed to antibiotics (IAP/postnatal)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 90-day old pre-tem neonates exposed to antibiotics (IAP/postnatal)
Lab analysis
Statistical Analysis
Signature 1
Source: Results for qtPCR within text under the subheading "Impact of Delivery Mode and Antibiotics Use on the Establishment of Intestinal Microbiota" (5th paragraph)
Description: Impact of Antibiotics Use on the Intestinal Microbiota between 90-day old pre-term neonates not exposed to antibiotics (IAP/postnatal) and 90-day old pre-term neonates exposed to antibiotics (IAP/postnatal)
Abundance in Group 1: decreased abundance in 90-day old pre-tem neonates exposed to antibiotics (IAP/postnatal)
NCBI | Quality Control | Links |
---|---|---|
Bifidobacterium |
Revision editor(s): WikiWorks, ChiomaBlessing