Oral bacterial community dynamics in paediatric patients with malignancies in relation to chemotherapy-related oral mucositis: a prospective study/Experiment 3
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Reviewed Marked as Reviewed by Claregrieve1 on 2023/01/26
Subjects
- Location of subjects
- Sweden
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Buccal mucosa , Lower lip Buccal mucosa,buccal mucosa,Labium inferius oris,Lower jaw lip,Lower lip,lower lip
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Oral mucositis inflammation of the mouth,oral cavity mucosal damage,oral mucosa irritation,oral mucosal damage,oral mucosal injury,oral mucosal lesions,stomatitis,Oral mucositis,oral mucositis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- at malignancy diagnosis
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- during chemotherapy
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- patients that are newly diagnosed with malignancies that are between ages 4 and 18 years old that are treated with cytostatic drug and has a national population registration number (Sweden) that has later developed oral mucositis (graded by the World Health Organization) during chemotherapy treatment
- Group 0 sample size Number of subjects in the control (unexposed) group
- 12
- Group 1 sample size Number of subjects in the case (exposed) group
- 12
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Roche454
Statistical Analysis
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age, sex
Signature 1
Reviewed Marked as Reviewed by Claregrieve1 on 2023/01/26
Source: Table 3
Description: Differential microbial abundance between the malignancy diagnosis (pre-chemotherapy) timepoint and during chemotherapy timepoint in those who have oral mucositis
Abundance in Group 1: increased abundance in during chemotherapy
| NCBI | Quality Control | Links |
|---|---|---|
| Staphylococcus |
Revision editor(s): Claregrieve1, WikiWorks
Signature 2
Reviewed Marked as Reviewed by Claregrieve1 on 2023/01/26
Source: Table 3
Description: Differential microbial abundance between the malignancy diagnosis (pre-chemotherapy) timepoint and during chemotherapy timepoint in those who have oral mucositis
Abundance in Group 1: decreased abundance in during chemotherapy
| NCBI | Quality Control | Links |
|---|---|---|
| Derxia | ||
| Pseudomonadota |
Revision editor(s): Claregrieve1, WikiWorks
