Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by Claregrieve1 on 2022/12/23
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Necrotizing enterocolitis Enterocolitis, Necrotizing,NEC,necrotizing enterocolitis,necrotizing enterocolitis in fetus or newborn,Necrotizing enterocolitis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- non-NEC
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- NEC
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- infants who underwent intestinal resection at <180 days of age with NEC
- Group 0 sample size Number of subjects in the control (unexposed) group
- 14
- Group 1 sample size Number of subjects in the case (exposed) group
- 10
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V1-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Roche454
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- raw counts
- Statistical test
- DESeq2
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.1
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Reviewed Marked as Reviewed by Claregrieve1 on 2022/12/23
Source: Figure 6
Description: Comparison of the abundance of tissue bacterial genera between infants with or without necrotizing enterocolitis (NEC) after adjusting
Abundance in Group 1: increased abundance in NEC
| NCBI | Quality Control | Links |
|---|---|---|
| Staphylococcus |
Revision editor(s): WikiWorks
