Association of prenatal antibiotics with measures of infant adiposity and the gut microbiome/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by Claregrieve1 on 2022/07/15
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Antimicrobial agent antibiotic,antibiotics,Antibiotika,Antibiotikum,antibiotique,antimicrobial,antimicrobial agents,microbicide,microbicides,Antimicrobial agent,antimicrobial agent
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 12-month-old infants not exposed to antibiotics during the second trimester
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 12-month-old infants exposed to antibiotics during the second trimester
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- infants born after 28 weeks gestation with no congenital abnormalities who were exposed to antibiotics during the second trimester
- Group 0 sample size Number of subjects in the control (unexposed) group
- 40
- Group 1 sample size Number of subjects in the case (exposed) group
- 10
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Statistical test
- Beta Binomial Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- body mass index, household income, smoking behavior, education level, marital status, maternal age, race
Signature 1
Reviewed Marked as Reviewed by Claregrieve1 on 2022/07/15
Source: Figure 1, Table S2
Description: Differential microbial abundance between infants who were and were not exposed to antibiotics in the second trimester
Abundance in Group 1: increased abundance in 12-month-old infants exposed to antibiotics during the second trimester
| NCBI | Quality Control | Links |
|---|---|---|
| Clostridium | ||
| Lachnospiraceae | ||
| Peptostreptococcaceae | ||
| Veillonella |
Revision editor(s): Claregrieve1, WikiWorks
Signature 2
Reviewed Marked as Reviewed by Claregrieve1 on 2022/10/6
Source: Figure 1, Table S2
Description: Differential microbial abundance between infants who were and were not exposed to antibiotics in the second trimester
Abundance in Group 1: decreased abundance in 12-month-old infants exposed to antibiotics during the second trimester
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia | ||
| Alistipes | ||
| Bacteroides | ||
| Blautia | ||
| Clostridium | ||
| Enterobacteriaceae | ||
| Gemmiger | ||
| Lachnoclostridium | ||
| Peptostreptococcaceae | ||
| Veillonella | ||
| Veillonella rogosae |
Revision editor(s): Claregrieve1, WikiWorks
