The gut microbiota is associated with psychiatric symptom severity and treatment outcome among individuals with serious mental illness

From BugSigDB
Needs review
study design
Citation
PMID PubMed identifier for scientific articles.
DOI Digital object identifier for electronic documents.
URI
Authors
Madan A, Thompson D, Fowler JC, Ajami NJ, Salas R, Frueh BC, Bradshaw MR, Weinstein BL, Oldham JM, Petrosino JF
Journal
Journal of affective disorders
Year
2020
Keywords:
Anxiety, Depression, Microbiome, Microbiota, Outcomes, Serious mental illness
BACKGROUND: Emerging evidence implicates the gut microbiota in central nervous system functioning via its effects on inflammation, the hypothalamic-pituitary axis, and/or neurotransmission. Our understanding of the cellular underpinnings of the brain-gut relationship is based almost exclusively on animal models with some small-scale human studies. This study examined the relationship between the gut microbiota and psychiatric symptom severity and treatment response among inpatients with serious mental illness. METHOD: We collected data from adult inpatients (N = 111). Measures of diagnoses, suicide severity, trauma, depression, and anxiety were collected shortly after admission, while self-collected fecal swabs were collected early in the course of hospitalization and processed using 16S rRNA gene sequencing and whole genome shotgun sequencing methods. RESULTS: Results indicate that depression and anxiety severity shortly after admission were negatively associated with bacterial richness and alpha diversity. Additional analyses revealed a number of bacterial taxa associated with depression and anxiety severity. Gut microbiota richness and alpha diversity early in the course of hospitalization was a significant predictor of depression remission at discharge. CONCLUSIONS: This study is among the first to demonstrate a gut microbiota relationship with symptom severity among psychiatric inpatients as well as a relationship to remission of depression post-treatment. These findings are consistent with animal models and limited human studies as well as with the broader literature implicating inflammation in the pathophysiology of depression. These findings offer the foundation for further studies of novel therapeutic approaches to the treatment, prevention of, or recurrence of serious mental illness.

Experiment 1


Needs review

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks

Subjects

Location of subjects
United States of America
Host species Species from which microbiome was sampled (if applicable)
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
unipolar depression Depression,Depression, Emotional,Depression, Endogenous,Depression, Involutional,Depression, Neurotic,Depression, Unipolar,Depressions,Depressions, Emotional,Depressions, Endogenous,Depressions, Neurotic,Depressions, Unipolar,DEPRESSIVE DIS,DEPRESSIVE DIS MAJOR,Depressive Disorder,Depressive Disorder, Major,Depressive Disorders,Depressive Disorders, Major,Depressive Neuroses,Depressive Neurosis,Depressive Symptom,Depressive Symptoms,Depressive Syndrome,Depressive Syndromes,Disorder, Depressive,Disorder, Major Depressive,Disorders, Depressive,Disorders, Major Depressive,Emotional Depression,Emotional Depressions,Endogenous Depression,Endogenous Depressions,Involutional Depression,Involutional Psychoses,Involutional Psychosis,MAJOR DEPRESSIVE DIS,major depressive disorder,Major Depressive Disorders,Neuroses, Depressive,Neurosis, Depressive,Neurotic Depression,Neurotic Depressions,Paraphrenia, Involutional,Psychoses, Involutional,Psychosis, Involutional,Symptom, Depressive,Symptoms, Depressive,Syndrome, Depressive,Syndromes, Depressive,Unipolar Depressions,unipolar depression
Group 0 name Corresponds to the control (unexposed) group for case-control studies
mild depression
Group 1 name Corresponds to the case (exposed) group for case-control studies
severe depression
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
psychiatric inpatients diagnosed by DSM-IV Disorders, SCID-I and SCID-II interviews, CSSR-S, SLEQ and GAD-7

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
2


Signature 1

Needs review

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, Merit

Source: Figure 1a,1b

Description: Bacterial biomarkers associated with depression severity with genus and species level resolution at admission

Abundance in Group 1: increased abundance in severe depression

NCBI Quality ControlLinks
Abyssicoccus albus
Flavonifractor plautii
Ruminococcus
Ruminococcus sp.

Revision editor(s): WikiWorks, Merit

Signature 2

Subject page title: The gut microbiota is associated with psychiatric symptom severity and treatment outcome among individuals with serious mental illness/Experiment 1/Signature 2
Reviewer: Rukky
Review date: 2023-3-28
Review state: Reviewed
Quality control tags:





Needs review

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): WikiWorks, Rukky

Source: Figure 1a,1b

Description: Bacterial biomarkers associated with depression severity with genus and species level resolution at admission

Abundance in Group 1: decreased abundance in severe depression

NCBI Quality ControlLinks
Actinomycetota
Alistipes senegalensis
Bifidobacterium adolescentis
Oxalobacter formigenes
Ruminococcaceae sp. B_A14
Oscillospiraceae bacterium

Revision editor(s): WikiWorks, Rukky

Experiment 2


Needs review

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
moderate depression

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): WikiWorks

Source: Figure 1a,1b

Description: Bacterial biomarkers associated with depression severity with genus and species level resolution at admission

Abundance in Group 1: increased abundance in moderate depression

NCBI Quality ControlLinks
Flavonifractor
Streptococcus anginosus
Coprococcus catus
[Clostridium] symbiosum

Revision editor(s): WikiWorks

Experiment 3


Needs review

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
anxiety disorder anxiety,anxiety disorder,anxiety disorders,anxiety neuroses,anxiety neurosis,anxiety state,anxiety/mood disorders,chronic stress,mood and anxiety disorder,mood and anxiety disorders,neurotic anxiety states
Group 0 name Corresponds to the control (unexposed) group for case-control studies
mild anxiety
Group 1 name Corresponds to the case (exposed) group for case-control studies
severe anxiety

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): WikiWorks, Atrayees

Source: Figure 1c, 1d

Description: Bacterial biomarkers associated with anxiety severity with genus and species level resolution at admission

Abundance in Group 1: increased abundance in severe anxiety

NCBI Quality ControlLinks
Streptococcus anginosus
Lachnospiraceae bacterium

Revision editor(s): WikiWorks, Atrayees

Signature 2

Needs review

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): WikiWorks, Merit

Source: Figure 1c, 1d

Description: Bacterial biomarkers associated with anxiety severity with genus and species level resolution at admission

Abundance in Group 1: decreased abundance in severe anxiety

NCBI Quality ControlLinks
Actinomycetes
Actinomycetota
Alistipes putredinis
Bacillota
Bifidobacterium adolescentis
Clostridia
Coprococcus catus
Corynebacteriaceae
Eubacteriales
Eubacterium ventriosum
Lawsonella
Mycobacteriales
Roseburia hominis
Roseburia inulinivorans
Actinomyces

Revision editor(s): WikiWorks, Merit

Experiment 4


Needs review

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
moderate anxiety

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): WikiWorks, Atrayees

Source: Figure 1c, 1d

Description: Bacterial biomarkers associated with anxiety severity with genus and species level resolution at admission

Abundance in Group 1: increased abundance in moderate anxiety

NCBI Quality ControlLinks
Lactococcus lactis
Lachnospiraceae bacterium

Revision editor(s): WikiWorks, Atrayees