Gut microbiome in ADHD and its relation to neural reward anticipation/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Subjects
- Location of subjects
- Netherlands
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Attention deficit hyperactivity disorder ADD,ADDH,ADHD,ATTENTION DEFICIT DIS,ATTENTION DEFICIT DIS WITH HYPERACTIVITY,Attention Deficit Disorder,attention deficit disorder,Attention Deficit Disorder with Hyperactivity,Attention Deficit Disorders,Attention Deficit Disorders with Hyperactivity,ATTENTION DEFICIT HYPERACTIVITY DIS,attention deficit hyperactivity disorder, inattentive type,attention deficit hyperactivity disorder, inattentive/distractible type,attention deficit hyperactivity disorder, predominantly inattentive type,Attention Deficit Hyperactivity Disorders,Brain Dysfunction, Minimal,Deficit Disorder, Attention,Deficit Disorders, Attention,Disorder, Attention Deficit,Disorders, Attention Deficit,Dysfunction, Minimal Brain,hyperkinetic disorder,Hyperkinetic Syndrome,Minimal Brain Dysfunction,Syndromes, Hyperkinetic,Attention deficit hyperactivity disorder,attention deficit hyperactivity disorder
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- ADHD
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- cases were diagnosed based on DSM-IV symptoms using the Schedule for Affective Disorders and Schizophrenia for School-Age Children
- Group 0 sample size Number of subjects in the control (unexposed) group
- 77
- Group 1 sample size Number of subjects in the case (exposed) group
- 19
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Roche454
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.1
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Source: Figure 3
Description: Differential abundance of microbial taxa for ADHD cases versus healthy controls
Abundance in Group 1: increased abundance in ADHD
Revision editor(s): WikiWorks
Signature 2
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Source: Figure 3
Description: Differential abundance of microbial taxa for ADHD cases versus healthy controls
Abundance in Group 1: decreased abundance in ADHD
| NCBI | Quality Control | Links |
|---|---|---|
| Bacillota | ||
| Clostridia | ||
| Eubacteriales | ||
| Coprococcus eutactus | ||
| Subdoligranulum | ||
| Ruminococcus | ||
| Acetivibrio | ||
| Coprococcus |
Revision editor(s): WikiWorks
