Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response

Study information

Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09

study design

case-control

Citation

PMID PubMed identifier for scientific articles.

28442250

DOI Digital object identifier for electronic documents.

10.1016/j.schres.2017.04.017

URI

Authors

Schwarz E, Maukonen J, Hyytiäinen T, Kieseppä T, Orešič M, Sabunciyan S, Mantere O, Saarela M, Yolken R, Suvisaari J

Journal

Schizophrenia research

Year

2018

Keywords:

Microbiome, Psychosis, Response, Schizophrenia

The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission.

Experiment 1

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Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, Victoria

Subjects

Location of subjects: Finland

Host species Species from which microbiome was sampled. Contact us to have more species added.: Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology: Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology: Psychosis mental or behavioural disorder,psychosis,psychotic disorder,Psychosis

Group 0 name Corresponds to the control (unexposed) group for case-control studies: Controls

Group 1 name Corresponds to the case (exposed) group for case-control studies: FIrst episode Psychosis

Group 0 sample size Number of subjects in the control (unexposed) group: 16

Group 1 sample size Number of subjects in the case (exposed) group: 28

Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any): 3 months

Lab analysis

Sequencing type: 16S

16S variable region One or more hypervariable region(s) of the bacterial 16S gene: Not specified

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance: Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).: relative abundances

Statistical test: LEfSe

Significance threshold p-value or FDR threshold used for differential abundance testing (if any): 0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?: No

LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool: 2

Matched on Factors on which subjects have been matched on in a case-control study: age, region of residence, sex

Signature 1

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Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): WikiWorks

Source: Figure 2

Description: Taxonomic differences of fecal microbiota between first episode psychosis patients and healthy controls

Abundance in Group 1: increased abundance in FIrst episode Psychosis

NCBI	Quality Control	Links
Brucellaceae
Lactobacillaceae
Halothiobacillaceae
Tropheryma
Ochrobactrum
Saccharophagus
Halorubrum
Lactobacillus
Deferribacter
Halothiobacillus
Lactobacillus acidophilus
Deferribacter desulfuricans
Burkholderia cenocepacia
Desulfosporosinus acidiphilus
Halothiobacillus neapolitanus
Saccharophagus degradans
Francisella hispaniensis
Tropheryma whipplei
Brucella canis
Lactobacillus johnsonii
Halorubrum lacusprofundi
Limosilactobacillus reuteri
Nitrosococcus halophilus
Bartonella clarridgeiae
Brucella anthropi
Bacillales
Hyphomicrobiales
Limosilactobacillus fermentum
Ligilactobacillus salivarius
Lactobacillus gasseri
Bifidobacterium dentium

Revision editor(s): WikiWorks

Signature 2

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Flag for review

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Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): Lwaldron, WikiWorks

Source: Figure 2

Description: Taxonomic differences of fecal microbiota between first episode psychosis patients and healthy controls

Abundance in Group 1: decreased abundance in FIrst episode Psychosis

NCBI	Quality Control	Links
Anabaena
Chlorobium chlorochromatii
Gallionella
Gallionella capsiferriformans
Negativicutes
Nitrosomonas sp.
Nitrosospira
Nitrosospira multiformis
Selenomonadales
Thermococcus gammatolerans
Trichormus variabilis
Veillonellaceae
Xenorhabdus nematophila
Leuconostoc gasicomitatum