Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients/Experiment 2

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Reviewed Marked as Reviewed by Fatima on 2022/04/20

Curated date: 2021/07/02

Curator: Claregrieve1

Revision editor(s): LGeistlinger, Claregrieve1, WikiWorks

Subjects

Location of subjects

China

Host species Species from which microbiome was sampled. Contact us to have more species added.

Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology

Rectum Intestinum rectum,Rectal sac,Terminal portion of intestine,Terminal portion of large intestine,Rectum,rectum

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

COVID-19 2019 novel coronavirus,2019 novel coronavirus infection,2019-nCoV,2019-nCoV infection,beta-CoV,beta-CoVs,betacoronavirus,coronavirus disease 2019,SARS-coronavirus 2,SARS-CoV-2,severe acute respiratory syndrome coronavirus 2,severe acute respiratory syndrome coronavirus 2 infectious disease,β-coronavirus,β-CoV,β-CoVs,COVID-19,cOVID-19

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Mild COVID-19 patients

Group 1 name Corresponds to the case (exposed) group for case-control studies

Severe COVID-19 patients

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

COVID-19 infected patients admitted to the ICU and requiring mechanical ventilation

Group 0 sample size Number of subjects in the control (unexposed) group

7

Group 1 sample size Number of subjects in the case (exposed) group

15

Lab analysis

Sequencing type

WMS

16S variable region One or more hypervariable region(s) of the bacterial 16S gene

Not specified

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance

DNBSEQ-T7

Statistical Analysis

Statistical test

Mann-Whitney (Wilcoxon)

Significance threshold p-value or FDR threshold used for differential abundance testing (if any)

0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?

No

Signature 1

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Reviewed Marked as Reviewed by Fatima on 2022/04/20

Curated date: 2021/07/02

Curator: Claregrieve1

Revision editor(s): Claregrieve1

Source: Supplementary Figure S6b

Description: Differential abundance in microbial taxa between mild and severe COVID-19 patients

Abundance in Group 1: increased abundance in Severe COVID-19 patients

NCBI	Quality Control	Links
Parabacteroides

Revision editor(s): Claregrieve1