Metagenome-wide association of gut microbiome features for schizophrenia/Experiment 4
From BugSigDB
Reviewed Marked as Reviewed by ChiomaBlessing on 2023-12-27
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Antipsychotic drug antipsychotic,antipsychotic agents,antipsychotic drugs,antipsychotics,antipsychotiques,grosser Tranquilizer,major tranquilizers,major tranquilizing agents,neuroleptic,neuroleptic agents,neuroleptics,Neuroleptikum,neuroleptique,neuroleptiques,Antipsychotic drug,antipsychotic drug
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Baseline Schizophrenic patients (38 participant subsample)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 3 Month Follow-up Schizophrenic patients (38 participant subsample)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Alterations in abundance of mOTUs in the gut of SCZ patients after 3-month antipsychotics treatment
- Group 0 sample size Number of subjects in the control (unexposed) group
- 38
- Group 1 sample size Number of subjects in the case (exposed) group
- 38
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 30 days
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- alcohol drinking, diet, demographics, smoking status, socioeconomic status
Signature 1
Reviewed Marked as Reviewed by ChiomaBlessing on 2023-12-27
Source: Supplementary Data 11
Description: Increased in 3 month follow-up schizophrenia patients treated with antipsychotics compared to baseline
Abundance in Group 1: increased abundance in 3 Month Follow-up Schizophrenic patients (38 participant subsample)
| NCBI | Quality Control | Links |
|---|---|---|
| Enterobacter cloacae | ||
| Klebsiella aerogenes |
Revision editor(s): Chloe
