Metagenome-wide association of gut microbiome features for schizophrenia/Experiment 4

From BugSigDB


Reviewed Marked as Reviewed by ChiomaBlessing on 2023-12-27

Curated date: 2024/01/03

Curator: Chloe

Revision editor(s): Chloe

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Antipsychotic drug antipsychotic,antipsychotic agents,antipsychotic drugs,antipsychotics,antipsychotiques,grosser Tranquilizer,major tranquilizers,major tranquilizing agents,neuroleptic,neuroleptic agents,neuroleptics,Neuroleptikum,neuroleptique,neuroleptiques,Antipsychotic drug,antipsychotic drug
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Baseline Schizophrenic patients (38 participant subsample)
Group 1 name Corresponds to the case (exposed) group for case-control studies
3 Month Follow-up Schizophrenic patients (38 participant subsample)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Alterations in abundance of mOTUs in the gut of SCZ patients after 3-month antipsychotics treatment
Group 0 sample size Number of subjects in the control (unexposed) group
38
Group 1 sample size Number of subjects in the case (exposed) group
38
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
30 days

Lab analysis

Sequencing type
WMS
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Statistical test
Mann-Whitney (Wilcoxon)
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes
Matched on Factors on which subjects have been matched on in a case-control study
alcohol drinking, diet, demographics, smoking status, socioeconomic status


Signature 1

Reviewed Marked as Reviewed by ChiomaBlessing on 2023-12-27

Curated date: 2024/01/03

Curator: Chloe

Revision editor(s): Chloe

Source: Supplementary Data 11

Description: Increased in 3 month follow-up schizophrenia patients treated with antipsychotics compared to baseline

Abundance in Group 1: increased abundance in 3 Month Follow-up Schizophrenic patients (38 participant subsample)

NCBI Quality ControlLinks
Enterobacter cloacae
Klebsiella aerogenes

Revision editor(s): Chloe