The microbiome of the oral mucosa in irritable bowel syndrome/Experiment 2

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Reviewed Marked as Reviewed by Fatima on 2021/07/16

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): Rimsha, Lwaldron, WikiWorks

Subjects

Location of subjects
United States of America
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Buccal mucosa Buccal mucosa,buccal mucosa
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Irritable bowel syndrome [X]Psychogenic IBS,Adaptive colitis,Colitides, Mucous,Colitis, Mucous,Colon spasm,Colon, Irritable,Functional bowel disease,IBD,IBS,IBS - Irritable bowel syndrome,IC - Irritable colon,Irritable bowel,Irritable bowel - IBS,irritable bowel syndrome,Irritable Bowel Syndromes,Irritable Colon,irritable colon,Irritable colon (disorder),Irritable colon - Irritable bowel syndrome,Irritable colon syndrome,Membranous colitis,Mucous Colitides,Mucous colitis,mucus colitis,Nervous colitis,Psychogenic IBS,psychogenic IBS,Spastic colitis,Spastic colon,spastic colon,Syndrome, Irritable Bowel,Syndromes, Irritable Bowel,Irritable bowel syndrome
Group 0 name Corresponds to the control (unexposed) group for case-control studies
control
Group 1 name Corresponds to the case (exposed) group for case-control studies
overweight irritable bowel syndrome
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
IBS are who suffered from chronic visceral pain and altered bowel habits for more than 6 months for which no organic cause had been identified
Group 0 sample size Number of subjects in the control (unexposed) group
20
Group 1 sample size Number of subjects in the case (exposed) group
11

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
PhyloChip

Statistical Analysis

Statistical test
Welch's T-Test
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
Matched on Factors on which subjects have been matched on in a case-control study
age, body weight, race, sex


Signature 1

Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks

Source: Figure 6

Description: OTUs showed significant differential abundance between healthy controls and IBS participants

Abundance in Group 1: increased abundance in overweight irritable bowel syndrome

NCBI Quality ControlLinks
Corynebacterium
Bifidobacterium
Atopobium
Olsenella
Bacillus
Planomicrobium
Lactobacillus
Pseudoramibacter
Oribacterium
Shuttleworthia
Dialister
Megasphaera
Selenomonas
Aquabacterium
Delftia
Campylobacter
Pseudomonas
Treponema
Prevotella
Staphylococcus

Revision editor(s): WikiWorks

Signature 2

Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09

Curated date: 2021/01/10

Curator: Rimsha Azhar

Revision editor(s): WikiWorks

Source: Figure 6

Description: OTUs showed significant differential abundance between healthy controls and IBS participants

Abundance in Group 1: decreased abundance in overweight irritable bowel syndrome

NCBI Quality ControlLinks
Aestuariimicrobium
Chryseobacterium
Haloanella
Dehalogenimonas
Gemella
Streptococcus
Neisseria
Haemophilus
Prevotella
Staphylococcus

Revision editor(s): WikiWorks