The early infant gut microbiome varies in association with a maternal high-fat diet/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Meconium Meconium,meconium
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- High fat diet HF - High fat diet,High fat diet (finding),High fat diet,high fat diet
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- nebowrns of maternal control
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- newborns of maternal high-fat diet
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- To determine maternal dietary intake during pregnancy, each mother was asked by trained personnel at each sample collection time point to answer the Dietary Screener Questionnaire (DSQ), which was developed and validated by the National Health and Examination Survey (NHANES) program (2009–2010)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 13
- Group 1 sample size Number of subjects in the case (exposed) group
- 13
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V5
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Roche454
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Signature 1
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Source: Figure 4
Description: Neonaatal meconium identified by LEfSe betwen maternal high-fat or maternal control diet during pregnancy
Abundance in Group 1: increased abundance in newborns of maternal high-fat diet
| NCBI | Quality Control | Links |
|---|---|---|
| Lactococcus | ||
| Granulicatella | ||
| Enterococcus |
Revision editor(s): WikiWorks
Signature 2
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Source: Figure 4
Description: Neonaatal meconium identified by LEfSe betwen maternal high-fat or maternal control diet during pregnancy
Abundance in Group 1: decreased abundance in newborns of maternal high-fat diet
| NCBI | Quality Control | Links |
|---|---|---|
| Sutterella | ||
| Parabacteroides | ||
| Bacteroides | ||
| Comamonas |
Revision editor(s): WikiWorks
