Racial Differences in the Oral Microbiome: Data from Low-Income Populations of African Ancestry and European Ancestry/Experiment 1

From BugSigDB


Needs review

Curated date: 2022/07/11

Curator: Kaluifeanyi101

Revision editor(s): Kaluifeanyi101, WikiWorks

Subjects

Location of subjects
United States of America
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Oral opening Mouth,Oral fissure,Oral orifice,Oral part of face,Oral opening,oral opening
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Ethnic group Ethnicity,race,Ethnic group,ethnic group
Group 0 name Corresponds to the control (unexposed) group for case-control studies
European Americans (EA)
Group 1 name Corresponds to the case (exposed) group for case-control studies
African Americans (AA)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Mouth rinse samples of 1,058 African Americans, with about 57% population with low SES of annual household income < $15,000.
Group 0 sample size Number of subjects in the control (unexposed) group
558
Group 1 sample size Number of subjects in the case (exposed) group
1058
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
12 Months

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Statistical test
Logistic Regression
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes
Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
age, alcohol drinking, body mass index, household income, sex, smoking status

Alpha Diversity

Richness Number of species
increased

Signature 1

Needs review

Curated date: 2022/07/11

Curator: Kaluifeanyi101

Revision editor(s): Kaluifeanyi101

Source: Table 2; Figure 3

Description: TABLE 2 Significantly higher abundance of Bacteroidetes and lower abundance of Actinobacteria and Firmicutes among African-Americans FIG 3 Thirteen common bacterial taxa showing a significant differential abundance between AAs and EAs in linear regression analyses.

Abundance in Group 1: increased abundance in African Americans (AA)

NCBI Quality ControlLinks
Porphyromonadaceae
Porphyromonas
Prevotella denticola
Peptostreptococcaceae

Revision editor(s): Kaluifeanyi101

Signature 2

Needs review

Curated date: 2022/07/11

Curator: Kaluifeanyi101

Revision editor(s): Kaluifeanyi101

Source: Table 2; Figure 3

Description: TABLE 2 Significantly higher abundance of Bacteroidetes and lower abundance of Actinobacteria and Firmicutes among African-Americans FIG 3 Thirteen common bacterial taxa showing a significant differential abundance between AAs and EAs in linear regression analyses.

Abundance in Group 1: decreased abundance in African Americans (AA)

NCBI Quality ControlLinks
Actinomycetota
Carnobacteriaceae
Granulicatella
Granulicatella adiacens
Micrococcaceae
Rothia
Rothia mucilaginosa
Streptococcus cristatus
Streptococcus sp. oral taxon 057

Revision editor(s): Kaluifeanyi101