Racial Differences in the Oral Microbiome: Data from Low-Income Populations of African Ancestry and European Ancestry/Experiment 1
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Oral opening Mouth,Oral fissure,Oral orifice,Oral part of face,Oral opening,oral opening
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Ethnic group Ethnicity,race,Ethnic group,ethnic group
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- European Americans (EA)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- African Americans (AA)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Mouth rinse samples of 1,058 African Americans, with about 57% population with low SES of annual household income < $15,000.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 558
- Group 1 sample size Number of subjects in the case (exposed) group
- 1058
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 12 Months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- -V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Statistical test
- Logistic Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- .05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, alcohol drinking, body mass index, household income, sex, smoking status
Alpha Diversity
- Richness Number of species
- increased
Signature 1
Source: Table 2; Figure 3
Description: TABLE 2 Significantly higher abundance of Bacteroidetes and lower abundance of Actinobacteria and Firmicutes among African-Americans FIG 3 Thirteen common bacterial taxa showing a significant differential abundance between AAs and EAs in linear regression analyses.
Abundance in Group 1: increased abundance in African Americans (AA)
| NCBI | Quality Control | Links |
|---|---|---|
| Porphyromonadaceae | ||
| Porphyromonas | ||
| Prevotella denticola | ||
| Peptostreptococcaceae |
Revision editor(s): Kaluifeanyi101
Signature 2
Source: Table 2; Figure 3
Description: TABLE 2 Significantly higher abundance of Bacteroidetes and lower abundance of Actinobacteria and Firmicutes among African-Americans FIG 3 Thirteen common bacterial taxa showing a significant differential abundance between AAs and EAs in linear regression analyses.
Abundance in Group 1: decreased abundance in African Americans (AA)
| NCBI | Quality Control | Links |
|---|---|---|
| Actinomycetota | ||
| Carnobacteriaceae | ||
| Granulicatella | ||
| Granulicatella adiacens | ||
| Micrococcaceae | ||
| Rothia | ||
| Rothia mucilaginosa | ||
| Streptococcus cristatus | ||
| Streptococcus sp. oral taxon 057 |
Revision editor(s): Kaluifeanyi101
