Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by Fatima on 2022/08/9

Curated date: 2022/07/12

Curator: Kaluifeanyi101

Revision editor(s): Kaluifeanyi101, Fatima, WikiWorks

Subjects

Location of subjects
Malaysia
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Ethnic group Ethnicity,race,Ethnic group,ethnic group
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Chinese
Group 1 name Corresponds to the case (exposed) group for case-control studies
Malay
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Malay ethnic group living in the Segamat Malaysian community.
Group 0 sample size Number of subjects in the control (unexposed) group
65
Group 1 sample size Number of subjects in the case (exposed) group
46

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Statistical test
Linear Regression
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes

Alpha Diversity

Pielou Quantifies how equal the community is numerically
unchanged
Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged

Signature 1

Reviewed Marked as Reviewed by Fatima on 2022/08/9

Curated date: 2022/07/12

Curator: Kaluifeanyi101

Revision editor(s): Kaluifeanyi101

Source: Figure 4.

Description: Multi-ethnic comparison of (a) gut enterotype profiles analyzed using Dirichlet Multinomial Model, and (b) Prevotella: Bacteroides ratio analyzed using a linear mixed model (likelihood ratio test p<0.05).

Abundance in Group 1: increased abundance in Malay

NCBI Quality ControlLinks
Prevotella

Revision editor(s): Kaluifeanyi101

Signature 2

Reviewed Marked as Reviewed by Fatima on 2022/08/9

Curated date: 2022/07/12

Curator: Kaluifeanyi101

Revision editor(s): Kaluifeanyi101, Fatima

Source: Figure 4, text

Description: Multi-ethnic comparison of (a) gut enterotype profiles analyzed using Dirichlet Multinomial Model, and (b) Prevotella: Bacteroides ratio analyzed using a linear mixed model (likelihood ratio test p<0.05).

Abundance in Group 1: decreased abundance in Malay

NCBI Quality ControlLinks
Bacteroides

Revision editor(s): Kaluifeanyi101, Fatima