Factors Associated With the Microbiome in Moderate-Late Preterm Babies: A Cohort Study From the DIAMOND Randomized Controlled Trial/Experiment 2

From BugSigDB


Needs review

Curated date: 2024/03/18

Curator: Scholastica

Revision editor(s): Scholastica

Subjects

Location of subjects
New Zealand
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Spontaneous preterm birth Spontaneous preterm birth,spontaneous preterm birth
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Higher SES (D10)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Lower SES (D10)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Moderate–late preterm (MLPT) babies at Day-10 (D10) whose families lived in the lower SES (socioeconomic status) areas
Group 0 sample size Number of subjects in the control (unexposed) group
59
Group 1 sample size Number of subjects in the case (exposed) group
80
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
None

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
MaAsLin2
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
increased

Signature 1

Needs review

Curated date: 2024/03/18

Curator: Scholastica

Revision editor(s): Scholastica

Source: Text (page 5)

Description: Significantly abundant taxa in MLPT babies from lower socioeconomic status (SES) group compared to the higher SES group at D10

Abundance in Group 1: increased abundance in Lower SES (D10)

NCBI Quality ControlLinks
Bifidobacterium

Revision editor(s): Scholastica