Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway/Experiment 5

From BugSigDB


Needs review

Curated date: 2022/09/20

Curator: Mary Bearkland

Revision editor(s): Mary Bearkland, Atrayees

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Mus musculus
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Antimicrobial agent antibiotic,antibiotics,Antibiotika,Antibiotikum,antibiotique,antimicrobial,antimicrobial agents,microbicide,microbicides,Antimicrobial agent,antimicrobial agent
Group 0 name Corresponds to the control (unexposed) group for case-control studies
control
Group 1 name Corresponds to the case (exposed) group for case-control studies
Vanc
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Group 1 mice were treated with vancomycin alone (0.25 mg/ml) in sterile drinking water (Vanc group) Mice (in all groups) were then subcutaneously injected into the right axillary with 0.25 live CT26 tumor cells.
Group 0 sample size Number of subjects in the control (unexposed) group
6
Group 1 sample size Number of subjects in the case (exposed) group
7

Lab analysis

Sequencing type
WMS
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Statistical test
Mann-Whitney (Wilcoxon)
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05


Signature 1

Reviewed Marked as Reviewed by Atrayees on 2023-7-14

Curated date: 2022/09/20

Curator: Mary Bearkland

Revision editor(s): Mary Bearkland

Source: supp fig 2

Description: Bar plot of compositional differences at species level in the Control vs. Coli groups of mice before PD-1 antibody treatment by one-way ANOVA.

Abundance in Group 1: increased abundance in Vanc

NCBI Quality ControlLinks
Akkermansia muciniphila
Akkermansia muciniphila CAG:154
Bacteroides sp. 2_1_33B
Bacteroides uniformis
Parabacteroides distasonis
Xylanibacter rarus
unclassified Bacteroidales
unclassified Bacteroides
unclassified Parabacteroides

Revision editor(s): Mary Bearkland

Signature 2

Reviewed Marked as Reviewed by Atrayees on 2023-7-14

Curated date: 2022/09/21

Curator: Mary Bearkland

Revision editor(s): Mary Bearkland

Source: supp fig 2

Description: Bar plot of compositional differences at species level in the Control vs. Vanc group of mice before PD-1 antibody treatment by one-way ANOVA.

Abundance in Group 1: decreased abundance in Vanc

NCBI Quality ControlLinks
Bacteroides sp. CAG:927
Firmicutes bacterium ASF500
Lachnospiraceae bacterium A4
Phocaeicola massiliensis
Prevotella sp. CAG:1031
Prevotella sp. CAG:873

Revision editor(s): Mary Bearkland