The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder/Experiment 2
Curated date: 2023/03/11
Curator: Jacquelynshevin
Revision editor(s): Fatima, Jacquelynshevin, Lwaldron
Subjects
- Location of subjects
- Germany
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Nasal cavity Cavitas nasalis,Cavitas nasi,Cavity of nose,Cavity of olfactory apparatus,Cavum nasi,Nasal canal,Nasal conduit space,Nasal fossa,Nasal pit,Olfactory cavity,Olfactory chamber,Olfactory chamber cavity,Olfactory pit,Nasal cavity,nasal cavity
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- REM sleep behavior disorder Rapid eye movement sleep behavior disorder,rapid eye movement sleep behavior disorder,REM Sleep Behavior Disorder,REM sleep behavior disorder,rEM sleep behavior disorder
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- idiopathic rapid eye movement sleep behavior disorder
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Subjects with iRBD diagnosed according to the consensus criteria of the International RBD Study group and no signs for neurodegenerative disorder (by clinical examination and neuropsychological testing).
- Group 0 sample size Number of subjects in the control (unexposed) group
- 78
- Group 1 sample size Number of subjects in the case (exposed) group
- 21
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- raw counts
- Statistical test
- DESeq2
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- .05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Curated date: 2023/03/11
Curator: Jacquelynshevin
Revision editor(s): Jacquelynshevin, Fatima, WikiWorks
Source: Results of the differential analysis of the nasal microbiota
Description: Summarized results of the differential analyses of the nasal microbiota at the family. Taxa with multiple‐testing adjusted P values below 0.05 (and an absolute log2 fold change > 1 for differential analyses) were defined as significantly differentially abundant or related to a continuous variable, respectively.
Abundance in Group 1: decreased abundance in idiopathic rapid eye movement sleep behavior disorder
| NCBI | Quality Control | Links |
|---|---|---|
| Bacillales incertae sedis | ||
| Desulfovibrionaceae | ||
| Oxalobacteraceae |
Revision editor(s): Jacquelynshevin, Fatima, WikiWorks
