Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare/Experiment 2
From BugSigDB
Reviewed Marked as Reviewed by Lwaldron on 2023-4-1
Subjects
- Location of subjects
- Singapore
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Skin epithelium Skin epithelium,skin epithelium
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Eczema Eczema,eczema
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Females (controls)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Females (cases)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Atopic dermatitis (AD) case females
- Group 0 sample size Number of subjects in the control (unexposed) group
- 7
- Group 1 sample size Number of subjects in the case (exposed) group
- 11
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age, sex
Signature 1
Reviewed Marked as Reviewed by Lwaldron on 2023-4-2
Curated date: 2023/03/30
Curator: Ufuoma Ejite
Revision editor(s): Ufuoma Ejite, Lwaldron, WikiWorks
Source: Supplementary Figure 6B
Description: Differential microbial abundance between female controls and female AD case group
Abundance in Group 1: decreased abundance in Females (cases)
| NCBI | Quality Control | Links |
|---|---|---|
| Dermacoccus | ||
| Methylobacterium |
Revision editor(s): Ufuoma Ejite, Lwaldron, WikiWorks
